Immunization with mycobacterium tuberculosis–Specific antigens bypasses T cell differentiation from prior bacillus calmette–Guérin vaccination and improves protection in mice
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Immunization with mycobacterium tuberculosis–Specific antigens bypasses T cell differentiation from prior bacillus calmette–Guérin vaccination and improves protection in mice. / Aagaard, Claus; Hell Knudsen, Niels Peter; Sohn, Iben; Izzo, Angelo A.; Kim, Hongmin; Kristiansen, Emma Holsey; Lindenstrøm, Thomas; Agger, Else Marie; Rasmussen, Michael; Shin, Sung Jae; Rosenkrands, Ida; Andersen, Peter; Mortensen, Rasmus.
In: Journal of Immunology, Vol. 205, No. 8, 2020, p. 2146-2155.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Immunization with mycobacterium tuberculosis–Specific antigens bypasses T cell differentiation from prior bacillus calmette–Guérin vaccination and improves protection in mice
AU - Aagaard, Claus
AU - Hell Knudsen, Niels Peter
AU - Sohn, Iben
AU - Izzo, Angelo A.
AU - Kim, Hongmin
AU - Kristiansen, Emma Holsey
AU - Lindenstrøm, Thomas
AU - Agger, Else Marie
AU - Rasmussen, Michael
AU - Shin, Sung Jae
AU - Rosenkrands, Ida
AU - Andersen, Peter
AU - Mortensen, Rasmus
PY - 2020
Y1 - 2020
N2 - Despite the fact that the majority of people in tuberculosis (TB)–endemic areas are vaccinated with the Bacillus Calmette–Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis–specific (or “non-BCG”) subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis–specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis–specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design. The Journal of Immunology, 2020, 205: 2146–2155.
AB - Despite the fact that the majority of people in tuberculosis (TB)–endemic areas are vaccinated with the Bacillus Calmette–Guérin (BCG) vaccine, TB remains the leading infectious cause of death. Data from both animal models and humans show that BCG and subunit vaccines induce T cells of different phenotypes, and little is known about how BCG priming influences subsequent booster vaccines. To test this, we designed a novel Mycobacterium tuberculosis–specific (or “non-BCG”) subunit vaccine with protective efficacy in both mice and guinea pigs and compared it to a known BCG boosting vaccine. In naive mice, this M. tuberculosis–specific vaccine induced similar protection compared with the BCG boosting vaccine. However, in BCG-primed animals, only the M. tuberculosis–specific vaccine added significantly to the BCG-induced protection. This correlated with the priming of T cells with a lower degree of differentiation and improved lung-homing capacity. These results have implications for TB vaccine design. The Journal of Immunology, 2020, 205: 2146–2155.
U2 - 10.4049/jimmunol.2000563
DO - 10.4049/jimmunol.2000563
M3 - Journal article
C2 - 32887748
AN - SCOPUS:85092324595
VL - 205
SP - 2146
EP - 2155
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 8
ER -
ID: 250817289