Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy
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Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy. / Krogh Nielsen, Marie; Subhi, Yousif; Molbech, Christopher Rue; Nilsson, Line Lynge; Nissen, Mogens Holst; Sørensen, Torben Lykke.
In: Acta Ophthalmologica, Vol. 97, No. 1, 2019, p. 84-90.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy
AU - Krogh Nielsen, Marie
AU - Subhi, Yousif
AU - Molbech, Christopher Rue
AU - Nilsson, Line Lynge
AU - Nissen, Mogens Holst
AU - Sørensen, Torben Lykke
PY - 2019
Y1 - 2019
N2 - Purpose Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age‐related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). Methods This was a prospective case–control study. A total of 125 participants were included consecutively during a period of 18 months. We included 46 patients with neovascular AMD, 46 patients with GA without any sign of choroidal neovascularization in either eye, and 33 healthy aged controls. Patients with immune‐affecting disorders were not included. Commercial immunoassay kits were used to quantify levels of TIMP‐1, TIMP‐3, MMP‐2 and MMP‐9 in blood plasma. Results We found that patients with neovascular AMD had lower plasma concentration of TIMP‐3 (p = 0.028) than healthy controls. Patients with GA had higher plasma levels of TIMP‐1 (p < 0.001) and MMP‐9 (p = 0.022) compared to healthy controls. Also, we found that TIMP‐1 levels in patients with GA increased with age (Spearman's rho = 0.04, p = 0.006). Conclusion Matrix metalloproteinases (MMPs) and TIMPs, which are known to be involved in age‐related changes in Bruch's membrane, are significantly altered systemically, suggesting the presence of an imbalance in the homeostasis of the extracellular matrix. These imbalances may explain differences in the clinical manifestation of late AMD.
AB - Purpose Tissue inhibitor of metalloproteinase (TIMP) is known to play a role in age‐related macular degeneration (AMD). We wished to investigate alterations in different late stages of AMD: neovascular AMD and geographic atrophy (GA). Methods This was a prospective case–control study. A total of 125 participants were included consecutively during a period of 18 months. We included 46 patients with neovascular AMD, 46 patients with GA without any sign of choroidal neovascularization in either eye, and 33 healthy aged controls. Patients with immune‐affecting disorders were not included. Commercial immunoassay kits were used to quantify levels of TIMP‐1, TIMP‐3, MMP‐2 and MMP‐9 in blood plasma. Results We found that patients with neovascular AMD had lower plasma concentration of TIMP‐3 (p = 0.028) than healthy controls. Patients with GA had higher plasma levels of TIMP‐1 (p < 0.001) and MMP‐9 (p = 0.022) compared to healthy controls. Also, we found that TIMP‐1 levels in patients with GA increased with age (Spearman's rho = 0.04, p = 0.006). Conclusion Matrix metalloproteinases (MMPs) and TIMPs, which are known to be involved in age‐related changes in Bruch's membrane, are significantly altered systemically, suggesting the presence of an imbalance in the homeostasis of the extracellular matrix. These imbalances may explain differences in the clinical manifestation of late AMD.
U2 - 10.1111/aos.13894
DO - 10.1111/aos.13894
M3 - Journal article
C2 - 30288950
VL - 97
SP - 84
EP - 90
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 1
ER -
ID: 203403712