IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation
Research output: Contribution to journal › Letter › Research › peer-review
High prevalence of IDH mutations in seronegative rheumatoid arthritis (RA) with myeloid neoplasm, elevated 2-hydroxyglutarate, dysregulated innate immunity, and proinflammatory microenvironment suggests causative association between IDH mutations and seronegative RA. Our findings merit investigation of IDH inhibitors as therapeutics for seronegative IDH-mutated RA.
Original language | English |
---|---|
Journal | Blood |
Volume | 143 |
Issue number | 18 |
Pages (from-to) | 1873–1877 |
ISSN | 0006-4971 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
Publisher Copyright:
© 2024 American Society of Hematology
ID: 388539360