TY - JOUR

T1 - Human papillomavirus related neoplasia of the ocular adnexa

AU - Ramberg, Ingvild

AU - Heegaard, Steffen

N1 - Funding Information: This research was funded by the Synoptik Foundation, Denmark; the Danish Eye Research Foundation, Denmark; the Fight for Sight Foundation, Denmark; the Faculty of Health and Medical Sciences, Copenhagen University, Denmark; the Svend Arvid Schr?der and Ketty Lydia Larsen Schr?der Foundation, Denmark; and Copenhagen University Hospital, Rigshospitalet, Denmark. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.

AB - Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.

KW - Conjunctiva

KW - Eyelids

KW - Human papillomavirus

KW - Lacrimal drainage system

KW - Ocular adnexa

KW - Sebaceous cell carcinoma

KW - Squamous cell carcinoma

KW - Squamous cell papilloma

U2 - 10.3390/v13081522

DO - 10.3390/v13081522

M3 - Review

C2 - 34452388

AN - SCOPUS:85112683933

VL - 13

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 8

M1 - 1522

ER -