Human eye colour and HERC2, OCA2 and MATP

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Human eye colour and HERC2, OCA2 and MATP. / Mengel-From, Jonas; Børsting, Claus; Sanchez, Juan J.; Eiberg, Hans; Morling, Niels.

In: Forensic Science International: Genetics, Vol. 4, No. 5, 12.01.2010, p. 323 - 328.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mengel-From, J, Børsting, C, Sanchez, JJ, Eiberg, H & Morling, N 2010, 'Human eye colour and HERC2, OCA2 and MATP', Forensic Science International: Genetics, vol. 4, no. 5, pp. 323 - 328. https://doi.org/DOI: 10.1016/j.fsigen.2009.12.004

APA

Mengel-From, J., Børsting, C., Sanchez, J. J., Eiberg, H., & Morling, N. (2010). Human eye colour and HERC2, OCA2 and MATP. Forensic Science International: Genetics, 4(5), 323 - 328. https://doi.org/DOI: 10.1016/j.fsigen.2009.12.004

Vancouver

Mengel-From J, Børsting C, Sanchez JJ, Eiberg H, Morling N. Human eye colour and HERC2, OCA2 and MATP. Forensic Science International: Genetics. 2010 Jan 12;4(5):323 - 328. https://doi.org/DOI: 10.1016/j.fsigen.2009.12.004

Author

Mengel-From, Jonas ; Børsting, Claus ; Sanchez, Juan J. ; Eiberg, Hans ; Morling, Niels. / Human eye colour and HERC2, OCA2 and MATP. In: Forensic Science International: Genetics. 2010 ; Vol. 4, No. 5. pp. 323 - 328.

Bibtex

@article{a5a434e5184c4ff184a589d61e0341d8,

title = "Human eye colour and HERC2, OCA2 and MATP",

abstract = "Prediction of human eye colour by forensic genetic methods is of great value in certain crime investigations. Strong associations between blue/brown eye colour and the SNP loci rs1129038 and rs12913832 in the HERC2 gene were recently described. Weaker associations between eye colour and other genetic markers also exist. In 395 randomly selected Danes, we investigated the predictive values of various combinations of SNP alleles in the HERC2, OCA2 and MATP (SLC45A2) genes and compared the results to the eye colours as they were described by the individuals themselves. The highest predictive value of typing either the HERC2 SNPs rs1129038 and/or rs12913832 that are in strong linkage disequilibrium was observed when eye colour was divided into two groups, (1) blue, grey and green (light) and (2) brown and hazel (dark). Sequence variations in rs11636232 and rs7170852 in HERC2, rs1800407 in OCA2 and rs16891982 in MATP showed additional association with eye colours in addition to the effect of HERC2 rs1129038. Diplotype analysis of three sequence variations in HERC2 and one sequence variation in OCA2 showed the best discrimination between light and dark eye colours with a likelihood ratio of 29.3.",

keywords = "Forensic",

author = "Jonas Mengel-From and Claus B{\o}rsting and Sanchez, {Juan J.} and Hans Eiberg and Niels Morling",

year = "2010",

month = jan,

day = "12",

doi = "DOI: 10.1016/j.fsigen.2009.12.004",

language = "English",

volume = "4",

pages = "323 -- 328",

journal = "Forensic Science International: Genetics",

issn = "1872-4973",

publisher = "Elsevier",

number = "5",

}

RIS

TY - JOUR

T1 - Human eye colour and HERC2, OCA2 and MATP

AU - Mengel-From, Jonas

AU - Børsting, Claus

AU - Sanchez, Juan J.

AU - Eiberg, Hans

AU - Morling, Niels

PY - 2010/1/12

Y1 - 2010/1/12

N2 - Prediction of human eye colour by forensic genetic methods is of great value in certain crime investigations. Strong associations between blue/brown eye colour and the SNP loci rs1129038 and rs12913832 in the HERC2 gene were recently described. Weaker associations between eye colour and other genetic markers also exist. In 395 randomly selected Danes, we investigated the predictive values of various combinations of SNP alleles in the HERC2, OCA2 and MATP (SLC45A2) genes and compared the results to the eye colours as they were described by the individuals themselves. The highest predictive value of typing either the HERC2 SNPs rs1129038 and/or rs12913832 that are in strong linkage disequilibrium was observed when eye colour was divided into two groups, (1) blue, grey and green (light) and (2) brown and hazel (dark). Sequence variations in rs11636232 and rs7170852 in HERC2, rs1800407 in OCA2 and rs16891982 in MATP showed additional association with eye colours in addition to the effect of HERC2 rs1129038. Diplotype analysis of three sequence variations in HERC2 and one sequence variation in OCA2 showed the best discrimination between light and dark eye colours with a likelihood ratio of 29.3.

AB - Prediction of human eye colour by forensic genetic methods is of great value in certain crime investigations. Strong associations between blue/brown eye colour and the SNP loci rs1129038 and rs12913832 in the HERC2 gene were recently described. Weaker associations between eye colour and other genetic markers also exist. In 395 randomly selected Danes, we investigated the predictive values of various combinations of SNP alleles in the HERC2, OCA2 and MATP (SLC45A2) genes and compared the results to the eye colours as they were described by the individuals themselves. The highest predictive value of typing either the HERC2 SNPs rs1129038 and/or rs12913832 that are in strong linkage disequilibrium was observed when eye colour was divided into two groups, (1) blue, grey and green (light) and (2) brown and hazel (dark). Sequence variations in rs11636232 and rs7170852 in HERC2, rs1800407 in OCA2 and rs16891982 in MATP showed additional association with eye colours in addition to the effect of HERC2 rs1129038. Diplotype analysis of three sequence variations in HERC2 and one sequence variation in OCA2 showed the best discrimination between light and dark eye colours with a likelihood ratio of 29.3.

KW - Forensic

U2 - DOI: 10.1016/j.fsigen.2009.12.004

DO - DOI: 10.1016/j.fsigen.2009.12.004

M3 - Journal article

VL - 4

SP - 323

EP - 328

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

SN - 1872-4973

IS - 5

ER -

ID: 33888559

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