Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach
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Human biomonitoring pilot study DEMOCOPHES in Germany : Contribution to a harmonized European approach. / Schwedler, Gerda; Seiwert, Margarete; Fiddicke, Ulrike; Ißleb, Sissy; Hölzer, Jürgen; Nendza, Julia; Wilhelm, Michael; Wittsiepe, Jürgen; Koch, Holger M.; Schindler, Birgit K.; Göen, Thomas; Hildebrand, Jörg; Joas, Reinhard; Joas, Anke; Casteleyn, Ludwine; Angerer, Jürgen; Castano, Argelia; Esteban, Marta; Schoeters, Greet; Den Hond, Elly; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Knudsen, Lisbeth E.; Kolossa-Gehring, Marike.
In: International Journal of Hygiene and Environmental Health, Vol. 220, No. 4, 06.2017, p. 686-696.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Human biomonitoring pilot study DEMOCOPHES in Germany
T2 - Contribution to a harmonized European approach
AU - Schwedler, Gerda
AU - Seiwert, Margarete
AU - Fiddicke, Ulrike
AU - Ißleb, Sissy
AU - Hölzer, Jürgen
AU - Nendza, Julia
AU - Wilhelm, Michael
AU - Wittsiepe, Jürgen
AU - Koch, Holger M.
AU - Schindler, Birgit K.
AU - Göen, Thomas
AU - Hildebrand, Jörg
AU - Joas, Reinhard
AU - Joas, Anke
AU - Casteleyn, Ludwine
AU - Angerer, Jürgen
AU - Castano, Argelia
AU - Esteban, Marta
AU - Schoeters, Greet
AU - Den Hond, Elly
AU - Sepai, Ovnair
AU - Exley, Karen
AU - Bloemen, Louis
AU - Knudsen, Lisbeth E.
AU - Kolossa-Gehring, Marike
PY - 2017/6
Y1 - 2017/6
N2 - Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries.In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6–11 year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study.The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV).German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS.Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern.Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe’s people against environmental health risks.
AB - Human biomonitoring (HBM) is an effective tool to assess human exposure to environmental pollutants, but comparable HBM data in Europe are lacking. In order to expedite harmonization of HBM studies on a European scale, the twin projects COPHES (Consortium to Perform Human Biomonitoring on a European Scale) and DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale) were formed, comprising 35 partners from 27 European countries.In COPHES a research scheme and guidelines were developed to exemplarily measure in a pilot study mercury in hair, cadmium, cotinine and several phthalate metabolites in urine of 6–11 year old children and their mothers in an urban and a rural region. Seventeen European countries simultaneously conducted this cross-sectional DEMOCOPHES feasibility study.The German study population was taken in the city of Bochum and in the Higher Sauerland District, comprising 120 mother-child pairs. In the present paper features of the study implementation are presented. German exposure concentrations of the pollutants are reported and compared with European average concentrations from DEMOCOPHES and with those measured in the representative German Environmental Survey (GerES IV).German DEMOCOPHES concentrations for mercury and cotinine were lower than the European average. However, 47% of the children were still exposed to environmental tobacco smoke (ETS) outside their home, which gives further potential for enhancing protection of children from ETS.Compared with samples from the other European countries German participating children had lower concentrations of the phthalate metabolites MEP and of the sum of 3 DEHP-metabolites (MEHP, 5OH-MEHP and 5oxo-MEHP), about the same concentrations of the phthalate metabolites MBzP and MiBP and higher concentrations of the phthalate metabolite MnBP. 2.5% of the German children had concentrations of the sum of 4 DEHP-metabolites and 4.2% had concentrations of MnBP that exceeded health based guidance values, indicating reasons for concern.Continuous HBM is necessary to track changes of pollutant exposure over time. Therefore Germany will continue to cooperate on the harmonisation of European human biomonitoring to support the chemicals regulation with the best possible exposure data to protect Europe’s people against environmental health risks.
U2 - 10.1016/j.ijheh.2017.01.012
DO - 10.1016/j.ijheh.2017.01.012
M3 - Journal article
C2 - 28254163
VL - 220
SP - 686
EP - 696
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
SN - 1438-4639
IS - 4
ER -
ID: 179170124