HIV infection is associated with thoracic and abdominal aortic aneurysms: A prospective matched cohort study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
HIV infection is associated with thoracic and abdominal aortic aneurysms : A prospective matched cohort study. / Høgh, Julie; Pham, Michael Huy Cuong; Knudsen, Andreas Dehlbæk; Thudium, Rebekka Faber; Gelpi, Marco; Sigvardsen, Per Ejlstrup; Fuchs, Andreas; Kühl, Jørgen Tobias; Afzal, Shoaib; Nordestgaard, Børge Grønne; Benfield, Thomas; Køber, Lars; Gerstoft, Jan; Kofoed, Klaus Fuglsang; Nielsen, Susanne Dam.
In: European Heart Journal, Vol. 42, No. 30, 2021, p. 2924-2931.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - HIV infection is associated with thoracic and abdominal aortic aneurysms
T2 - A prospective matched cohort study
AU - Høgh, Julie
AU - Pham, Michael Huy Cuong
AU - Knudsen, Andreas Dehlbæk
AU - Thudium, Rebekka Faber
AU - Gelpi, Marco
AU - Sigvardsen, Per Ejlstrup
AU - Fuchs, Andreas
AU - Kühl, Jørgen Tobias
AU - Afzal, Shoaib
AU - Nordestgaard, Børge Grønne
AU - Benfield, Thomas
AU - Køber, Lars
AU - Gerstoft, Jan
AU - Kofoed, Klaus Fuglsang
AU - Nielsen, Susanne Dam
N1 - Publisher Copyright: © 2021 Published on behalf of the European Society of Cardiology. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Aims: Little is known about the prevalence of aortic aneurysms among people living with HIV (PLWH). We investigated whether HIV status is independently associated with having aortic aneurysms. Furthermore, we determined risk factors associated with aortic aneurysms in PLWH. Methods and results: PLWH aged ≥40 years (n = 594) were recruited from the Copenhagen Comorbidity in HIV Infection study and matched for age and sex with uninfected controls (n = 1188) from the Copenhagen General Population Study. Aortic dimensions were assessed using contrast enhanced computed tomography. Aortic aneurysms were defined according to the European Society of Cardiology guidelines, i.e. an aortic dilation of ≥50% or an infrarenal aortic diameter of ≥30 mm. Among PLWH and uninfected controls, the median (interquartile range) age was 52 (47-60) and 52 (48-61) and 88% and 90% were male, respectively. We found 46 aneurysms in 42 (7.1%) PLWH and 31 aneurysms in 29 (2.4%) uninfected controls (P < 0.001). PLWH had a significantly higher prevalence of ascending aortic aneurysms and infrarenal aortic aneurysms. In an adjusted model, HIV was independently associated with aortic aneurysms (adjusted odds ratio; 4.51 [95% confidence interval 2.56-8.08], P < 0.001). Within PLWH, obesity and hepatitis B co-infection were associated with aortic aneurysms. Conclusion: PLWH had four-fold higher odds of aortic aneurysms compared to uninfected controls, and HIV status was independently associated with aortic aneurysms. Among PLWH, age, obesity and hepatitis B co-infection were associated with higher odds of aortic aneurysms. Our findings suggest that increased attention to aortic aneurysms in PLWH may be beneficial.
AB - Aims: Little is known about the prevalence of aortic aneurysms among people living with HIV (PLWH). We investigated whether HIV status is independently associated with having aortic aneurysms. Furthermore, we determined risk factors associated with aortic aneurysms in PLWH. Methods and results: PLWH aged ≥40 years (n = 594) were recruited from the Copenhagen Comorbidity in HIV Infection study and matched for age and sex with uninfected controls (n = 1188) from the Copenhagen General Population Study. Aortic dimensions were assessed using contrast enhanced computed tomography. Aortic aneurysms were defined according to the European Society of Cardiology guidelines, i.e. an aortic dilation of ≥50% or an infrarenal aortic diameter of ≥30 mm. Among PLWH and uninfected controls, the median (interquartile range) age was 52 (47-60) and 52 (48-61) and 88% and 90% were male, respectively. We found 46 aneurysms in 42 (7.1%) PLWH and 31 aneurysms in 29 (2.4%) uninfected controls (P < 0.001). PLWH had a significantly higher prevalence of ascending aortic aneurysms and infrarenal aortic aneurysms. In an adjusted model, HIV was independently associated with aortic aneurysms (adjusted odds ratio; 4.51 [95% confidence interval 2.56-8.08], P < 0.001). Within PLWH, obesity and hepatitis B co-infection were associated with aortic aneurysms. Conclusion: PLWH had four-fold higher odds of aortic aneurysms compared to uninfected controls, and HIV status was independently associated with aortic aneurysms. Among PLWH, age, obesity and hepatitis B co-infection were associated with higher odds of aortic aneurysms. Our findings suggest that increased attention to aortic aneurysms in PLWH may be beneficial.
KW - Aortic aneurysm
KW - Comorbidity
KW - Computed tomography imaging
KW - HIV
KW - Syphilis
U2 - 10.1093/eurheartj/ehab348
DO - 10.1093/eurheartj/ehab348
M3 - Journal article
C2 - 34240121
AN - SCOPUS:85113817965
VL - 42
SP - 2924
EP - 2931
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 30
ER -
ID: 279184275