Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas
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Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas. / Marquard, L.; Poulsen, C.B.; Gjerdrum, L.M.; Brown, P. de Nully; Christensen, I.J.; Jensen, P.B.; Sehested, M.; Johansen, P.; Ralfkiaer, E.
In: Histopathology, Vol. 54, No. 6, 2009, p. 688-698.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Histone deacetylase 1, 2, 6 and acetylated histone H4 in B- and T-cell lymphomas
AU - Marquard, L.
AU - Poulsen, C.B.
AU - Gjerdrum, L.M.
AU - Brown, P. de Nully
AU - Christensen, I.J.
AU - Jensen, P.B.
AU - Sehested, M.
AU - Johansen, P.
AU - Ralfkiaer, E.
PY - 2009
Y1 - 2009
N2 - AIMS: Histone deacetylase (HDAC) inhibitors are novel therapeutics in the treatment of peripheral T-cell lymphoma, unspecified (PTCL) and diffuse large B-cell lymphoma (DLBCL), where, for unknown reasons, T-cell malignancies appear to be more sensitive than B-cell malignancies. The aim was to determine HDAC expression in DLBCL and PTCL which has not previously been investigated. METHODS AND RESULTS: The expression of HDAC1, HDAC2, HDAC6 and acetylated histone H4 was examined immunohistochemically in 31 DLBCL and 45 PTCL. All four markers showed high expression in both DLBCL and PTCL compared with normal lymphoid tissue. HDAC1 was more abundantly expressed in PTCL than in DLBCL (P = 0.0046), whereas acetylated H4 was more frequent in DLBCL (P < 0.0001), the latter suggesting a mechanism for T-cell lymphoma sensitivity to HDAC inhibitors. Moderate to strong HDAC6 expression was significantly correlated with favourable outcome (P = 0.016) in DLBCL patients, whereas the opposite effect was observed in PTCL patients (P < 0.0001). The other markers did not correlate with survival (P > 0.05). CONCLUSIONS: HDAC1, HDAC2, HDAC6 and acetylated H4 are overexpressed in DLBCL and PTCL relative to normal lymphoid tissue. Furthermore, HDAC6 may be an important prognostic marker associated with favourable outcome in DLBCL and a more aggressive course in PTCL Udgivelsesdato: 2009/5
AB - AIMS: Histone deacetylase (HDAC) inhibitors are novel therapeutics in the treatment of peripheral T-cell lymphoma, unspecified (PTCL) and diffuse large B-cell lymphoma (DLBCL), where, for unknown reasons, T-cell malignancies appear to be more sensitive than B-cell malignancies. The aim was to determine HDAC expression in DLBCL and PTCL which has not previously been investigated. METHODS AND RESULTS: The expression of HDAC1, HDAC2, HDAC6 and acetylated histone H4 was examined immunohistochemically in 31 DLBCL and 45 PTCL. All four markers showed high expression in both DLBCL and PTCL compared with normal lymphoid tissue. HDAC1 was more abundantly expressed in PTCL than in DLBCL (P = 0.0046), whereas acetylated H4 was more frequent in DLBCL (P < 0.0001), the latter suggesting a mechanism for T-cell lymphoma sensitivity to HDAC inhibitors. Moderate to strong HDAC6 expression was significantly correlated with favourable outcome (P = 0.016) in DLBCL patients, whereas the opposite effect was observed in PTCL patients (P < 0.0001). The other markers did not correlate with survival (P > 0.05). CONCLUSIONS: HDAC1, HDAC2, HDAC6 and acetylated H4 are overexpressed in DLBCL and PTCL relative to normal lymphoid tissue. Furthermore, HDAC6 may be an important prognostic marker associated with favourable outcome in DLBCL and a more aggressive course in PTCL Udgivelsesdato: 2009/5
M3 - Journal article
VL - 54
SP - 688
EP - 698
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 6
ER -
ID: 19687311