Histamine and the regulation of body weight.

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Standard

Histamine and the regulation of body weight. / Jørgensen, Emilie A; Knigge, Ulrich; Warberg, Jørgen; Kjaer, Andreas.

In: Neuroendocrinology, Vol. 86, No. 3, 2007, p. 210-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, EA, Knigge, U, Warberg, J & Kjaer, A 2007, 'Histamine and the regulation of body weight.', Neuroendocrinology, vol. 86, no. 3, pp. 210-4. https://doi.org/10.1159/000108341

APA

Jørgensen, E. A., Knigge, U., Warberg, J., & Kjaer, A. (2007). Histamine and the regulation of body weight. Neuroendocrinology, 86(3), 210-4. https://doi.org/10.1159/000108341

Vancouver

Jørgensen EA, Knigge U, Warberg J, Kjaer A. Histamine and the regulation of body weight. Neuroendocrinology. 2007;86(3):210-4. https://doi.org/10.1159/000108341

Author

Jørgensen, Emilie A ; Knigge, Ulrich ; Warberg, Jørgen ; Kjaer, Andreas. / Histamine and the regulation of body weight. In: Neuroendocrinology. 2007 ; Vol. 86, No. 3. pp. 210-4.

Bibtex

@article{e81d40c0accc11ddb538000ea68e967b,
title = "Histamine and the regulation of body weight.",
abstract = "Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter. In the present article we review current evidence pointing at an important role of histamine in the regulation of appetite and metabolism. Studies using both knockout mouse models as well as pharmacological studies have revealed that histamine acts as an anorexigenic agent via stimulation of histamine H(1) receptors. One effect of histamine in the regulation of appetite is to act as a mediator of the inhibitory effect of leptin on appetite. It seems that histamine may attenuate and delay the development of leptin resistance in high-fat-diet-induced obesity. Furthermore, histamine may also act to accelerate lipolysis. Based on the current evidence of the involvement of histamine in the regulation of body weight, the histaminergic system is an obvious target for the development of pharmacological agents to control obesity. At present, H(3) receptor antagonists that stimulate the histaminergic system may be the most promising histaminergic drugs for antiobesity therapy.",
author = "J{\o}rgensen, {Emilie A} and Ulrich Knigge and J{\o}rgen Warberg and Andreas Kjaer",
note = "Keywords: Animals; Appetite Regulation; Body Weight; Energy Metabolism; Histamine; Humans; Neurosecretory Systems; Obesity; Receptors, Histamine",
year = "2007",
doi = "10.1159/000108341",
language = "English",
volume = "86",
pages = "210--4",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Histamine and the regulation of body weight.

AU - Jørgensen, Emilie A

AU - Knigge, Ulrich

AU - Warberg, Jørgen

AU - Kjaer, Andreas

N1 - Keywords: Animals; Appetite Regulation; Body Weight; Energy Metabolism; Histamine; Humans; Neurosecretory Systems; Obesity; Receptors, Histamine

PY - 2007

Y1 - 2007

N2 - Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter. In the present article we review current evidence pointing at an important role of histamine in the regulation of appetite and metabolism. Studies using both knockout mouse models as well as pharmacological studies have revealed that histamine acts as an anorexigenic agent via stimulation of histamine H(1) receptors. One effect of histamine in the regulation of appetite is to act as a mediator of the inhibitory effect of leptin on appetite. It seems that histamine may attenuate and delay the development of leptin resistance in high-fat-diet-induced obesity. Furthermore, histamine may also act to accelerate lipolysis. Based on the current evidence of the involvement of histamine in the regulation of body weight, the histaminergic system is an obvious target for the development of pharmacological agents to control obesity. At present, H(3) receptor antagonists that stimulate the histaminergic system may be the most promising histaminergic drugs for antiobesity therapy.

AB - Energy intake and expenditure is regulated by a complex interplay between peripheral and central factors. An exhaustive list of peptides and neurotransmitters taking part in this complex regulation of body weight exists. Among these is histamine, which acts as a central neurotransmitter. In the present article we review current evidence pointing at an important role of histamine in the regulation of appetite and metabolism. Studies using both knockout mouse models as well as pharmacological studies have revealed that histamine acts as an anorexigenic agent via stimulation of histamine H(1) receptors. One effect of histamine in the regulation of appetite is to act as a mediator of the inhibitory effect of leptin on appetite. It seems that histamine may attenuate and delay the development of leptin resistance in high-fat-diet-induced obesity. Furthermore, histamine may also act to accelerate lipolysis. Based on the current evidence of the involvement of histamine in the regulation of body weight, the histaminergic system is an obvious target for the development of pharmacological agents to control obesity. At present, H(3) receptor antagonists that stimulate the histaminergic system may be the most promising histaminergic drugs for antiobesity therapy.

U2 - 10.1159/000108341

DO - 10.1159/000108341

M3 - Journal article

C2 - 17848791

VL - 86

SP - 210

EP - 214

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 3

ER -

ID: 8464729