Hemoglobin adducts of acrylamide in human blood - What has been done and what is next?

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Hemoglobin adducts of acrylamide in human blood - What has been done and what is next? / Pedersen, Marie; Vryonidis, Efstathios; Joensen, Andrea; Törnqvist, Margareta.

In: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 161, 112799, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Pedersen, M, Vryonidis, E, Joensen, A & Törnqvist, M 2022, 'Hemoglobin adducts of acrylamide in human blood - What has been done and what is next?', Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, vol. 161, 112799. https://doi.org/10.1016/j.fct.2021.112799

APA

Pedersen, M., Vryonidis, E., Joensen, A., & Törnqvist, M. (2022). Hemoglobin adducts of acrylamide in human blood - What has been done and what is next? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 161, [112799]. https://doi.org/10.1016/j.fct.2021.112799

Vancouver

Pedersen M, Vryonidis E, Joensen A, Törnqvist M. Hemoglobin adducts of acrylamide in human blood - What has been done and what is next? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022;161. 112799. https://doi.org/10.1016/j.fct.2021.112799

Author

Pedersen, Marie ; Vryonidis, Efstathios ; Joensen, Andrea ; Törnqvist, Margareta. / Hemoglobin adducts of acrylamide in human blood - What has been done and what is next?. In: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 ; Vol. 161.

Bibtex

@article{03936341e61a4fe3915bb9bd1cea299f,
title = "Hemoglobin adducts of acrylamide in human blood - What has been done and what is next?",
abstract = "Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the placenta and has been associated with restriction of intrauterine growth and certain cancers. The impact on human health is poorly understood and it is impossible to say what level of dietary exposure to acrylamide can be deemed safe as the assessment of exposure is uncertain. The determination of hemoglobin (Hb) adducts from acrylamide is increasingly being used to improve the exposure assessment of acrylamide. We aim to outline the literature on Hb adduct levels from acrylamide in humans and discuss methodological issues and research gaps. A total of 86 studies of 27,966 individuals from 19 countries were reviewed. Adduct levels were highest in occupationally exposed individuals and smokers. Levels ranged widely from 3 to 210 pmol/g Hb in non-smokers and this wide range suggests that dietary exposure to acrylamide varies largely. Non-smokers from the US and Canada had slightly higher levels as compared with non-smokers from elsewhere, but differences within studies were larger than between studies. Large studies with exposure assessment of acrylamide and related adduct forming compounds from diet during early-life are encouraged for the evaluation of health effects.",
author = "Marie Pedersen and Efstathios Vryonidis and Andrea Joensen and Margareta T{\"o}rnqvist",
note = "Copyright {\textcopyright} 2021. Published by Elsevier Ltd.",
year = "2022",
doi = "10.1016/j.fct.2021.112799",
language = "English",
volume = "161",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Hemoglobin adducts of acrylamide in human blood - What has been done and what is next?

AU - Pedersen, Marie

AU - Vryonidis, Efstathios

AU - Joensen, Andrea

AU - Törnqvist, Margareta

N1 - Copyright © 2021. Published by Elsevier Ltd.

PY - 2022

Y1 - 2022

N2 - Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the placenta and has been associated with restriction of intrauterine growth and certain cancers. The impact on human health is poorly understood and it is impossible to say what level of dietary exposure to acrylamide can be deemed safe as the assessment of exposure is uncertain. The determination of hemoglobin (Hb) adducts from acrylamide is increasingly being used to improve the exposure assessment of acrylamide. We aim to outline the literature on Hb adduct levels from acrylamide in humans and discuss methodological issues and research gaps. A total of 86 studies of 27,966 individuals from 19 countries were reviewed. Adduct levels were highest in occupationally exposed individuals and smokers. Levels ranged widely from 3 to 210 pmol/g Hb in non-smokers and this wide range suggests that dietary exposure to acrylamide varies largely. Non-smokers from the US and Canada had slightly higher levels as compared with non-smokers from elsewhere, but differences within studies were larger than between studies. Large studies with exposure assessment of acrylamide and related adduct forming compounds from diet during early-life are encouraged for the evaluation of health effects.

AB - Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the placenta and has been associated with restriction of intrauterine growth and certain cancers. The impact on human health is poorly understood and it is impossible to say what level of dietary exposure to acrylamide can be deemed safe as the assessment of exposure is uncertain. The determination of hemoglobin (Hb) adducts from acrylamide is increasingly being used to improve the exposure assessment of acrylamide. We aim to outline the literature on Hb adduct levels from acrylamide in humans and discuss methodological issues and research gaps. A total of 86 studies of 27,966 individuals from 19 countries were reviewed. Adduct levels were highest in occupationally exposed individuals and smokers. Levels ranged widely from 3 to 210 pmol/g Hb in non-smokers and this wide range suggests that dietary exposure to acrylamide varies largely. Non-smokers from the US and Canada had slightly higher levels as compared with non-smokers from elsewhere, but differences within studies were larger than between studies. Large studies with exposure assessment of acrylamide and related adduct forming compounds from diet during early-life are encouraged for the evaluation of health effects.

U2 - 10.1016/j.fct.2021.112799

DO - 10.1016/j.fct.2021.112799

M3 - Review

C2 - 34995709

VL - 161

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

M1 - 112799

ER -

ID: 289156382