GLP-1 increases microvascular recruitment but not glucose uptake in human and rat skeletal muscle
Research output: Contribution to journal › Journal article › Research › peer-review
The insulinotropic gut hormone, glucagon-like-peptide-1 (GLP-1) has been proposed to have effects on vascular function and glucose disposal. However, whether GLP-1 is able to increase microvascular recruitment (MVR) in humans has not been investigated. GLP-1 was infused in the femoral artery in overnight fasted healthy young men. Microvascular recruitment was measured with real time contrast-enhanced ultrasound and leg glucose uptake by the leg balance technique with and without inhibition of the insulinotropic response of GLP-1 by co-infusion of octreotide. As a positive control, MVR and leg glucose uptake were measured during a hyperinsulinemic euglycemic clamp. Infusion of GLP-1 caused a rapid increase (P
Original language | English |
---|---|
Journal | American Journal of Physiology: Endocrinology and Metabolism |
Volume | 306 |
Issue number | 4 |
Pages (from-to) | E355-E362 |
Number of pages | 8 |
ISSN | 0193-1849 |
DOIs | |
Publication status | Published - 2014 |
ID: 92062721