Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141
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Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141. / Hounmanou, Yaovi M.G.; Sit, Brandon; Fakoya, Bolutife; Waldor, Matthew K.; Dalsgaard, Anders.
In: Emerging Infectious Diseases , Vol. 28, No. 3, 2022, p. 617-624.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141
AU - Hounmanou, Yaovi M.G.
AU - Sit, Brandon
AU - Fakoya, Bolutife
AU - Waldor, Matthew K.
AU - Dalsgaard, Anders
N1 - Publisher Copyright: © 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2022
Y1 - 2022
N2 - Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non-O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulated pilus, as well as a type 3 secretion system. They had widely variable capacities for intestinal colonization in the infant mouse model. We propose that O141 isolates comprise a distinct clade of V. cholerae non-O1/O139, and their continued surveillance is warranted.
AB - Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non-O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulated pilus, as well as a type 3 secretion system. They had widely variable capacities for intestinal colonization in the infant mouse model. We propose that O141 isolates comprise a distinct clade of V. cholerae non-O1/O139, and their continued surveillance is warranted.
U2 - 10.3201/eid2803.210715
DO - 10.3201/eid2803.210715
M3 - Journal article
C2 - 35202520
AN - SCOPUS:85125170322
VL - 28
SP - 617
EP - 624
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
SN - 1080-6040
IS - 3
ER -
ID: 299206128