Genomet og diabetes
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Genomet og diabetes. / Allin, Kristine Højgaard; Hansen, Torben; Pedersen, Oluf Borbye.
In: Ugeskrift for Laeger, Vol. 176, No. 23, V06140337, 10.11.2014, p. 2176-2179.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genomet og diabetes
AU - Allin, Kristine Højgaard
AU - Hansen, Torben
AU - Pedersen, Oluf Borbye
PY - 2014/11/10
Y1 - 2014/11/10
N2 - In terms of their genetic architecture monogenic diabetes and type 2 diabetes represent two extremes. Whereas each subtype of monogenic diabetes is caused by one penetrant, rare mutation in a single gene, the genetic susceptibility to type 2 diabetes can be attributed to many low-penetrant variants across the genome. At present, only 10% of the genetic susceptibility to type 2 diabetes can be explained by the hitherto identified 90 genomic loci. Here we briefly review the genetics of monogenic diabetes and type 2 diabetes and outline future directions of research within this field.
AB - In terms of their genetic architecture monogenic diabetes and type 2 diabetes represent two extremes. Whereas each subtype of monogenic diabetes is caused by one penetrant, rare mutation in a single gene, the genetic susceptibility to type 2 diabetes can be attributed to many low-penetrant variants across the genome. At present, only 10% of the genetic susceptibility to type 2 diabetes can be explained by the hitherto identified 90 genomic loci. Here we briefly review the genetics of monogenic diabetes and type 2 diabetes and outline future directions of research within this field.
M3 - Tidsskriftartikel
C2 - 25394935
VL - 176
SP - 2176
EP - 2179
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 23
M1 - V06140337
ER -
ID: 148552424