Genetic burden of MS risk variants distinguish patients from healthy individuals but are not associated with disease activity
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Genetic burden of MS risk variants distinguish patients from healthy individuals but are not associated with disease activity. / Søndergaard, Helle Bach; Petersen, Eva Rosa; Magyari, Melinda; Sellebjerg, Finn; Oturai, Annette Bang.
In: Multiple Sclerosis and Related Disorders, Vol. 13, 2017, p. 25-27.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic burden of MS risk variants distinguish patients from healthy individuals but are not associated with disease activity
AU - Søndergaard, Helle Bach
AU - Petersen, Eva Rosa
AU - Magyari, Melinda
AU - Sellebjerg, Finn
AU - Oturai, Annette Bang
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2017
Y1 - 2017
N2 - Weighted genetic risk score (wGRS) was analysed for association with disease activity in more than 500 MS patients before and during interferon-beta treatment. The wGRS was higher in MS patients than in healthy controls when analysing eight HLA - and 109 non-HLA MS risk gene variants. No significant associations were observed between number of relapses prior to or during treatment with interferon-beta, both with and without HLA risk alleles included in the wGRS. In conclusion, among Danes the wGRS was higher in MS patients than controls but was not associated with the overall disease activity or response to treatment with interferon-beta.
AB - Weighted genetic risk score (wGRS) was analysed for association with disease activity in more than 500 MS patients before and during interferon-beta treatment. The wGRS was higher in MS patients than in healthy controls when analysing eight HLA - and 109 non-HLA MS risk gene variants. No significant associations were observed between number of relapses prior to or during treatment with interferon-beta, both with and without HLA risk alleles included in the wGRS. In conclusion, among Danes the wGRS was higher in MS patients than controls but was not associated with the overall disease activity or response to treatment with interferon-beta.
KW - Adult
KW - Alleles
KW - Female
KW - Genetic Predisposition to Disease
KW - HLA Antigens/genetics
KW - Humans
KW - Interferon-beta/therapeutic use
KW - Male
KW - Multiple Sclerosis/drug therapy
KW - Polymorphism, Single Nucleotide
KW - Risk Factors
U2 - 10.1016/j.msard.2017.01.015
DO - 10.1016/j.msard.2017.01.015
M3 - Journal article
C2 - 28427696
VL - 13
SP - 25
EP - 27
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -
ID: 194769466