Gastrointestinal symptom burden in diabetic autonomic and peripheral neuropathy – A Danes cohort study
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Gastrointestinal symptom burden in diabetic autonomic and peripheral neuropathy – A Danes cohort study. / Kufaishi, Huda; Mizrak, Hatice Isik; Brock, Birgitte; Hansen, Tine Willum; Rossing, Peter; Hansen, Christian Stevns.
In: Journal of Diabetes and its Complications, Vol. 38, No. 5, 108745, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Gastrointestinal symptom burden in diabetic autonomic and peripheral neuropathy – A Danes cohort study
AU - Kufaishi, Huda
AU - Mizrak, Hatice Isik
AU - Brock, Birgitte
AU - Hansen, Tine Willum
AU - Rossing, Peter
AU - Hansen, Christian Stevns
N1 - Publisher Copyright: © 2024
PY - 2024
Y1 - 2024
N2 - Objective: We investigated associations between gastrointestinal symptoms - evaluated as a combined weighted symptom score (CWSS) – Diabetic autonomic neuropathy (DAN), and distal symmetrical polyneuropathy (DSPN) in type 1 and type 2 diabetes. Research design and methods: Cross-sectional study in a tertiary outpatient clinic. CWSS was calculated based on questionnaires: gastroparesis composite symptom index (GCSI) and gastrointestinal symptom rating score (GSRS). DAN and DSPN were addressed using the composite autonomic symptom score 31 (COMPASS-31) questionnaire, cardiac autonomic reflex tests (CARTs), electrochemical skin conductance (ESC), vibration perception threshold (VPT), Michigan Neuropathy Screening Instrument (MNSI), pain- and thermal sensation. Analyses were adjusted for age, sex, diabetes duration, smoking, LDL-cholesterol, HbA1C and systolic blood pressure. Type 1 and type 2 diabetes were evaluated separately. Results: We included 566 with type 1 diabetes and 377 with type 2 diabetes. Mean ± SD age was 58 ± 15 years and 565 (59.9 %) were women. A high CWSS was present in 143 (25 %) with type 1 and 142 (38 %) with type 2 diabetes. The odds of DAN by COMPASS-31 (p < 0.001) were higher in the high score group. For type 1 diabetes, odds of cardiac autonomic neuropathy were higher in the high CWSS group. The odds of DSPN by VPT and MNSI in type 1 diabetes, and by ESC, VPT and pain sensation in type 2 diabetes were higher in the high CWSS group. Conclusions: A high symptom score was associated with neuropathy by COMPASS-31 and vibration perception. Gastrointestinal symptom burden associated inconsistently with other neuropathy tests between diabetes types.
AB - Objective: We investigated associations between gastrointestinal symptoms - evaluated as a combined weighted symptom score (CWSS) – Diabetic autonomic neuropathy (DAN), and distal symmetrical polyneuropathy (DSPN) in type 1 and type 2 diabetes. Research design and methods: Cross-sectional study in a tertiary outpatient clinic. CWSS was calculated based on questionnaires: gastroparesis composite symptom index (GCSI) and gastrointestinal symptom rating score (GSRS). DAN and DSPN were addressed using the composite autonomic symptom score 31 (COMPASS-31) questionnaire, cardiac autonomic reflex tests (CARTs), electrochemical skin conductance (ESC), vibration perception threshold (VPT), Michigan Neuropathy Screening Instrument (MNSI), pain- and thermal sensation. Analyses were adjusted for age, sex, diabetes duration, smoking, LDL-cholesterol, HbA1C and systolic blood pressure. Type 1 and type 2 diabetes were evaluated separately. Results: We included 566 with type 1 diabetes and 377 with type 2 diabetes. Mean ± SD age was 58 ± 15 years and 565 (59.9 %) were women. A high CWSS was present in 143 (25 %) with type 1 and 142 (38 %) with type 2 diabetes. The odds of DAN by COMPASS-31 (p < 0.001) were higher in the high score group. For type 1 diabetes, odds of cardiac autonomic neuropathy were higher in the high CWSS group. The odds of DSPN by VPT and MNSI in type 1 diabetes, and by ESC, VPT and pain sensation in type 2 diabetes were higher in the high CWSS group. Conclusions: A high symptom score was associated with neuropathy by COMPASS-31 and vibration perception. Gastrointestinal symptom burden associated inconsistently with other neuropathy tests between diabetes types.
KW - Cardiovascular autonomic neuropathy
KW - COMPASS-31
KW - Complications
KW - Diabetic neuropathies
KW - Diabetic neuropathy
KW - Distal peripheral neuropathy
KW - Enteric nervous system
KW - Enteropathy distal symmetric polyneuropathy
KW - Gastrointestinal motility
KW - Gastrointestinal symptoms
KW - Gastroparesis
KW - GCSI
KW - GSRS
KW - Type 1 diabetes
KW - Type 2 diabetes
U2 - 10.1016/j.jdiacomp.2024.108745
DO - 10.1016/j.jdiacomp.2024.108745
M3 - Journal article
C2 - 38615421
AN - SCOPUS:85190092937
VL - 38
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 5
M1 - 108745
ER -
ID: 389506320