Functions of TopBP1 in preserving genome integrity during mitosis
Research output: Contribution to journal › Review › Research › peer-review
TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.
Original language | English |
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Journal | Seminars in Cell and Developmental Biology |
Volume | 113 |
Pages (from-to) | 57-64 |
Number of pages | 8 |
ISSN | 1084-9521 |
DOIs | |
Publication status | Published - 2021 |
- Anaphase Bridges, Homologous recombination, MDC1, MiDAS, Mitosis, SLX4, TopBP1
Research areas
ID: 249857994