Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine
Research output: Contribution to journal › Journal article › Research › peer-review
Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.
Original language | English |
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Journal | Cephalalgia |
Volume | 30 |
Issue number | 9 |
Pages (from-to) | 1110-22 |
Number of pages | 13 |
ISSN | 0333-1024 |
DOIs | |
Publication status | Published - 1 Sep 2010 |
ID: 34126581