From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure
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From science to policy : How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure. / Gerofke, Antje; David, Madlen; Schmidt, Phillipp; Vicente, Joana Lobo; Buekers, Jurgen; Gilles, Liese; Colles, Ann; Bessems, Jos; Bastiaensen, Michiel; Covaci, Adrian; Den Hond, Elly; Koppen, Gudrun; Laeremans, Michelle; Verheyen, Veerle J.; Černá, Milena; Klánová, Jana; Krsková, Andrea; Zvonař, Martin; Knudsen, Lisbeth E.; Koch, Holger M.; Jensen, Tina Kold; Rambaud, Loïc; Riou, Margaux; Vogel, Nina; Gabriel, Catherine; Karakitsios, Spyros; Papaioannou, Nafsika; Sarigiannis, Denis; Kakucs, Réka; Középesy, Szilvia; Rudnai, Péter; Szigeti, Tamás; Barbone, Fabio; Rosolen, Valentina; Guignard, Cedric; Gutleb, Arno C.; Sakhi, Amrit Kaur; Haug, Line Småstuen; Janasik, Beata; Ligocka, Danuta; Estokova, Milada; Fabelova, Lucia; Kolena, Branislav; Murinova, Lubica Palkovicova; Petrovicova, Ida; Richterova, Denisa; Horvat, Milena; Mazej, Darja; Tratnik, Janja Snoj; Runkel, Agneta Annika; Castaño, Argelia; Esteban-López, Marta; Pedraza-Díaz, Susana; Åkesson, Agneta; Lignell, Sanna; Vlaanderen, Jelle; Zock, Jan Paul; Schoeters, Greet; Kolossa-Gehring, Marike.
In: International Journal of Hygiene and Environmental Health, Vol. 247, 114073, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - From science to policy
T2 - How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure
AU - Gerofke, Antje
AU - David, Madlen
AU - Schmidt, Phillipp
AU - Vicente, Joana Lobo
AU - Buekers, Jurgen
AU - Gilles, Liese
AU - Colles, Ann
AU - Bessems, Jos
AU - Bastiaensen, Michiel
AU - Covaci, Adrian
AU - Den Hond, Elly
AU - Koppen, Gudrun
AU - Laeremans, Michelle
AU - Verheyen, Veerle J.
AU - Černá, Milena
AU - Klánová, Jana
AU - Krsková, Andrea
AU - Zvonař, Martin
AU - Knudsen, Lisbeth E.
AU - Koch, Holger M.
AU - Jensen, Tina Kold
AU - Rambaud, Loïc
AU - Riou, Margaux
AU - Vogel, Nina
AU - Gabriel, Catherine
AU - Karakitsios, Spyros
AU - Papaioannou, Nafsika
AU - Sarigiannis, Denis
AU - Kakucs, Réka
AU - Középesy, Szilvia
AU - Rudnai, Péter
AU - Szigeti, Tamás
AU - Barbone, Fabio
AU - Rosolen, Valentina
AU - Guignard, Cedric
AU - Gutleb, Arno C.
AU - Sakhi, Amrit Kaur
AU - Haug, Line Småstuen
AU - Janasik, Beata
AU - Ligocka, Danuta
AU - Estokova, Milada
AU - Fabelova, Lucia
AU - Kolena, Branislav
AU - Murinova, Lubica Palkovicova
AU - Petrovicova, Ida
AU - Richterova, Denisa
AU - Horvat, Milena
AU - Mazej, Darja
AU - Tratnik, Janja Snoj
AU - Runkel, Agneta Annika
AU - Castaño, Argelia
AU - Esteban-López, Marta
AU - Pedraza-Díaz, Susana
AU - Åkesson, Agneta
AU - Lignell, Sanna
AU - Vlaanderen, Jelle
AU - Zock, Jan Paul
AU - Schoeters, Greet
AU - Kolossa-Gehring, Marike
N1 - Publisher Copyright: © 2022 The Authors
PY - 2023
Y1 - 2023
N2 - Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences. The impact indicator revealed that health risks based on exposure to DiBP cannot be excluded. This is an indication or flag for risk managers and policy makers that exposure to DiBP still is a relevant health issue. HBM indicators derived within HBM4EU are a valuable and important complement to existing indicator lists in the context of environment and health. Their applicability, current shortcomings and solution strategies are outlined.
AB - Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences. The impact indicator revealed that health risks based on exposure to DiBP cannot be excluded. This is an indication or flag for risk managers and policy makers that exposure to DiBP still is a relevant health issue. HBM indicators derived within HBM4EU are a valuable and important complement to existing indicator lists in the context of environment and health. Their applicability, current shortcomings and solution strategies are outlined.
KW - DINCH
KW - HBM4EU
KW - Human biomonitoring (HBM)
KW - indicator
KW - Phthalates
KW - Science-policy uptake
U2 - 10.1016/j.ijheh.2022.114073
DO - 10.1016/j.ijheh.2022.114073
M3 - Review
C2 - 36434900
AN - SCOPUS:85142480375
VL - 247
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
SN - 1438-4639
M1 - 114073
ER -
ID: 337595105