This article addresses frequently asked questions about the adverse drug reactions associated with methylphenidate treatment. Methylphenidate is a central nervous system stimulant used primarily for the treatment of attention-deficit/hyperactivity disorder. It utilizes insights from the combined knowledge of pharmacists and physicians who advise healthcare professionals in the Capital Region of Denmark on patient-specific medication queries. The article provides an overview of the clinical challenges and safety considerations associated with methylphenidate use, integrating empirical data and clinical expertise to facilitate informed decision-making by practitioners.