FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY
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FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY. / MOHR, H; KRAGSTRUP, J.
In: Fluoride - Quarterly Reports, Vol. 23, No. 4, 10.1990, p. 154-163.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - FLUORIDE EFFECT ON THE EPIPHYSEAL GROWTH PLATE EVALUATED BY VERTICAL SECTION STEREOLOGY
AU - MOHR, H
AU - KRAGSTRUP, J
PY - 1990/10
Y1 - 1990/10
N2 - The objective of this study was to describe the effects of fluoride on the epiphyses of the rat tibia by a newly developed histomorphometric technique for estimation of surface density and surface area of highly organized (anisotropic) organs: vertical section stereology. Seventeen experimental animals receiving drinking water with 100 ppm fluoride for seven weeks were compared with 16 controls. The proximal epiphyseal plate of the right tibia was examined. Morphometric estimates were obtained from vertical sections, i.e., histologic sections cut perpendicular to a defined plane. The thickness of the growth plate was significantly smaller in the fluoride group compared to controls (p < 0.05) due to a reduced thickness of the proliferative zone (p < 0.01). The surface density as well as the total volume of cells in the proliferative zone were significantly reduced in the fluoride group (p < 0.05). It was concluded that fluoride induces quantitative changes in the epiphyseal plate of the rat tibia probably by an effect on supracellular mechanisms.
AB - The objective of this study was to describe the effects of fluoride on the epiphyses of the rat tibia by a newly developed histomorphometric technique for estimation of surface density and surface area of highly organized (anisotropic) organs: vertical section stereology. Seventeen experimental animals receiving drinking water with 100 ppm fluoride for seven weeks were compared with 16 controls. The proximal epiphyseal plate of the right tibia was examined. Morphometric estimates were obtained from vertical sections, i.e., histologic sections cut perpendicular to a defined plane. The thickness of the growth plate was significantly smaller in the fluoride group compared to controls (p < 0.05) due to a reduced thickness of the proliferative zone (p < 0.01). The surface density as well as the total volume of cells in the proliferative zone were significantly reduced in the fluoride group (p < 0.05). It was concluded that fluoride induces quantitative changes in the epiphyseal plate of the rat tibia probably by an effect on supracellular mechanisms.
KW - BONE MODELING
KW - EPIPHYSEAL PLATE
KW - FLUORIDE
KW - HISTOMORPHOMETRY
KW - VERTICAL SECTIONS
KW - EXPERIMENTAL OSTEO-FLUOROSIS
KW - SKELETAL DEVELOPMENT
KW - DENTAL FLUOROSIS
KW - SODIUM-FLUORIDE
KW - TRABECULAR BONE
KW - OSTEOPOROSIS
KW - GIRLS
KW - CELLS
KW - AREA
KW - PIG
M3 - Journal article
VL - 23
SP - 154
EP - 163
JO - Fluoride - Quarterly Reports
JF - Fluoride - Quarterly Reports
SN - 0015-4725
IS - 4
ER -
ID: 324332680