Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial
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Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial. / Sass, Laerke; Bjarnadóttir, Elín; Stokholm, Jakob; Chawes, Bo; Vinding, Rebecca K; Mora-Jensen, Anna-Rosa C; Thorsen, Jonathan; Nørgaard, Sarah; Ebdrup, Bjørn H; Jepsen, Jens R M; Fagerlund, Birgitte; Bønnelykke, Klaus; Lauritzen, Lotte; Bisgaard, Hans.
In: Child Development, Vol. 92, No. 4, 2021, p. 1624-1635.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial
AU - Sass, Laerke
AU - Bjarnadóttir, Elín
AU - Stokholm, Jakob
AU - Chawes, Bo
AU - Vinding, Rebecca K
AU - Mora-Jensen, Anna-Rosa C
AU - Thorsen, Jonathan
AU - Nørgaard, Sarah
AU - Ebdrup, Bjørn H
AU - Jepsen, Jens R M
AU - Fagerlund, Birgitte
AU - Bønnelykke, Klaus
AU - Lauritzen, Lotte
AU - Bisgaard, Hans
N1 - © 2021 Society for Research in Child Development.
PY - 2021
Y1 - 2021
N2 - A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.
AB - A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.
U2 - 10.1111/cdev.13541
DO - 10.1111/cdev.13541
M3 - Journal article
C2 - 33506965
VL - 92
SP - 1624
EP - 1635
JO - Child Development
JF - Child Development
SN - 0009-3920
IS - 4
ER -
ID: 255887746