First-trimester combined screening for Down syndrome: prediction of low birth weight, small for gestational age and pre-term delivery in a cohort of non-selected women
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: To establish the relationship between the first-trimester screening markers [pregnancy-associated plasma protein A (PAPP-A), free human chorionic gonadotrophin-beta (beta-hCG), nuchal translucency (NT)], the Down syndrome (DS) risk estimate, and the adverse outcomes such as low birth weight, small for gestational age (SGA) and pre-term delivery.
METHODS: A retrospective cohort study including 1,734 non-selected singleton pregnancies consecutively enrolled into the programme of first-trimester combined screening for DS in a 12-month period at a single centre. Data from the Prenatal Patient Registry in ASTRAIA were combined with the Danish National Newborn Screening Registry and Danish Birth Registry.
RESULTS: There was a significant relation between low PAPP-A MoM, low beta-hCG MoM, increased risk estimate for DS and low birth weight and SGA. Low PAPP-A MoM and increased NT showed a significant relation to pre-term and spontaneous pre-term delivery. Low PAPP-A MoM showed a significant relation to early pre-term delivery.
CONCLUSION: First-trimester screening markers exhibited a significant relation to low birth weight, SGA and to some extent, to pre-term and early pre-term delivery. The screening performance of individual markers was poor.
Original language | English |
---|---|
Journal | Prenatal Diagnosis |
Volume | 28 |
Issue number | 3 |
Pages (from-to) | 247-53 |
Number of pages | 7 |
ISSN | 0197-3851 |
DOIs | |
Publication status | Published - Mar 2008 |
- Adult, Chorionic Gonadotropin, beta Subunit, Human, Cohort Studies, Down Syndrome, Female, Gestational Age, Humans, Infant, Low Birth Weight, Infant, Newborn, Mass Screening, Nuchal Translucency Measurement, Obstetric Labor, Premature, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, First, Pregnancy-Associated Plasma Protein-A, Retrospective Studies, Journal Article, Research Support, Non-U.S. Gov't
Research areas
ID: 179628813