First isolation of Leptospira fainei serovar Hurstbridge from two human patients with Weil's syndrome
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First isolation of Leptospira fainei serovar Hurstbridge from two human patients with Weil's syndrome. / Petersen, A. M.; Boye, K.; Blom, J.; Schlichting, P.; Krogfelt, K. A.
In: Journal of Medical Microbiology, Vol. 50, No. 1, 01.01.2001, p. 96-100.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - First isolation of Leptospira fainei serovar Hurstbridge from two human patients with Weil's syndrome
AU - Petersen, A. M.
AU - Boye, K.
AU - Blom, J.
AU - Schlichting, P.
AU - Krogfelt, K. A.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Leptospira fainei serovar Hurstbridge is a recently discovered Leptospira species and so far it has only been cultured from animal sources. Based on positive serology and positive PCR for L. fainei among patients suspected of having leptospirosis, a role in human disease seems likely. This study describes two patients with Weil's disease from whom L. fainei was cultured. A local source of the infections was suspected, as these two patients resided in the same area of Denmark, were hospitalised approximately at the same time and had not been travelling recently. The Leptospira species was determined by serology, PCR and sequencing of bacterial DNA. One patient developed autoimmune hepatitis in the course of the L. fainei infection and was treated with both antibiotics and immunosuppression with good effect. The other patient had a self-limiting disease and did not receive any treatment.
AB - Leptospira fainei serovar Hurstbridge is a recently discovered Leptospira species and so far it has only been cultured from animal sources. Based on positive serology and positive PCR for L. fainei among patients suspected of having leptospirosis, a role in human disease seems likely. This study describes two patients with Weil's disease from whom L. fainei was cultured. A local source of the infections was suspected, as these two patients resided in the same area of Denmark, were hospitalised approximately at the same time and had not been travelling recently. The Leptospira species was determined by serology, PCR and sequencing of bacterial DNA. One patient developed autoimmune hepatitis in the course of the L. fainei infection and was treated with both antibiotics and immunosuppression with good effect. The other patient had a self-limiting disease and did not receive any treatment.
UR - http://www.scopus.com/inward/record.url?scp=0035161379&partnerID=8YFLogxK
U2 - 10.1099/0022-1317-50-1-96
DO - 10.1099/0022-1317-50-1-96
M3 - Journal article
C2 - 11192512
AN - SCOPUS:0035161379
VL - 50
SP - 96
EP - 100
JO - Journal of Medical Microbiology
JF - Journal of Medical Microbiology
SN - 0022-2615
IS - 1
ER -
ID: 203887895