Filopodia: integrating cellular functions with theoretical models
Research output: Contribution to journal › Review › Research › peer-review
Standard
Filopodia : integrating cellular functions with theoretical models. / Ruhoff, Victoria Thusgaard; Leijnse, Natascha; Doostmohammadi, Amin; Bendix, Poul Martin.
In: Trends in Cell Biology, 2024.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Filopodia
T2 - integrating cellular functions with theoretical models
AU - Ruhoff, Victoria Thusgaard
AU - Leijnse, Natascha
AU - Doostmohammadi, Amin
AU - Bendix, Poul Martin
N1 - Funding Information: P.M.B. acknowledges funding from the Novo Nordisk Foundation (grant nos. NFF20OC0065357 and NFF20OC0061176). A.D. acknowledges funding from the Novo Nordisk Foundation (grant no. NNF18SA0035142 and NERD grant no. NNF21OC0068687), Villum Fonden grant no. 29476, and the European Union via the ERC-Starting Grant PhysCoMeT, grant no. 101041418. The authors declare no competing financial interests. Funding Information: This work is financially supported by the Novo Nordisk Foundation . P.M.B. and V.T.R. are funded by grant nos. NNF20OC0065357 and NNF20OC0061176 . A.D. and N.L. are funded by ERC-Starting Grant PhysCoMeT no. 101041418 . Publisher Copyright: © 2024 Elsevier Ltd
PY - 2024
Y1 - 2024
N2 - Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell–cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.
AB - Filopodia, widely distributed on cell surfaces, are distinguished by their dynamic extensions, playing pivotal roles in a myriad of biological processes. Their functions span from mechanosensing and guidance to cell–cell communication during cellular organization in the early embryo. Filopodia have significant roles in pathogenic processes, such as cancer invasion and viral dissemination. Molecular mapping of the filopodome has revealed generic components essential for filopodia functions. In parallel, recent insights into biophysical mechanisms governing filopodia dynamics have provided the foundation for broader investigations of filopodia's biological functions. We highlight recent discoveries of engagement of filopodia in various stages of development and pathogenesis and present an overview of intricate molecular and physical features of these cellular structures across a spectrum of cellular activities.
KW - cell communication
KW - cell invasion
KW - cell motility
KW - filopodia dynamics
KW - filopodia rotation
KW - mechanosensing
U2 - 10.1016/j.tcb.2024.05.005
DO - 10.1016/j.tcb.2024.05.005
M3 - Review
C2 - 38969554
AN - SCOPUS:85197629268
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
ER -
ID: 402889564