Fibroblast growth factor 21 in patients with cardiac cachexia: a possible role of chronic inflammation
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Fibroblast growth factor 21 in patients with cardiac cachexia : a possible role of chronic inflammation. / Refsgaard Holm, Maria; Christensen, Heidi; Rasmussen, Jon; Johansen, Marie Louise; Schou, Morten; Faber, Jens; Kistorp, Caroline.
In: ESC heart failure, Vol. 6, No. 5, 2019, p. 983-991.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Fibroblast growth factor 21 in patients with cardiac cachexia
T2 - a possible role of chronic inflammation
AU - Refsgaard Holm, Maria
AU - Christensen, Heidi
AU - Rasmussen, Jon
AU - Johansen, Marie Louise
AU - Schou, Morten
AU - Faber, Jens
AU - Kistorp, Caroline
PY - 2019
Y1 - 2019
N2 - AIMS: Cardiac cachexia is a wasting syndrome characterized by chronic inflammation and high mortality. Fibroblast growth factor 21 (FGF-21) and monocyte chemoattractant protein 1 (MCP-1) are associated with cardiovascular disease and systemic inflammation. We investigated FGF-21 and MCP-1 in relations to cardiac function, inflammation, and wasting in patients with heart failure with reduced ejection fraction (HFrEF) and cardiac cachexia.METHODS AND RESULTS: Plasma FGF-21 and MCP-1 were measured in a cross-sectional study among the three study groups: 19 patients with HFrEF with cardiac cachexia, 19 patients with HFrEF without cachexia, and 19 patients with ischaemic heart disease and preserved ejection fraction. Patients with HFrEF and cardiac cachexia displayed higher FGF-21 levels median (inter quantile range) 381 (232-577) pg/mL than patients with HFrEF without cachexia 224 (179-309) pg/mL and ischaemic heart disease patients 221 (156-308) pg/mL (P = 0.0496). No difference in MCP-1 levels were found among the groups (P = 0.345). In a multivariable regression analysis, FGF-21 (logarithm 2) was independently associated with interleukin 6 (logarithm 2) (P = 0.015) and lower muscle mass (P = 0.043), while no relation with N-terminal pro-hormone brain natriuretic peptide was observed.CONCLUSIONS: Fibroblast growth factor 21 (FGF-21) levels were elevated in patients with HFrEF and cardiac cachexia, which could be mediated by increased inflammation and muscle wasting rather than impaired cardiac function.
AB - AIMS: Cardiac cachexia is a wasting syndrome characterized by chronic inflammation and high mortality. Fibroblast growth factor 21 (FGF-21) and monocyte chemoattractant protein 1 (MCP-1) are associated with cardiovascular disease and systemic inflammation. We investigated FGF-21 and MCP-1 in relations to cardiac function, inflammation, and wasting in patients with heart failure with reduced ejection fraction (HFrEF) and cardiac cachexia.METHODS AND RESULTS: Plasma FGF-21 and MCP-1 were measured in a cross-sectional study among the three study groups: 19 patients with HFrEF with cardiac cachexia, 19 patients with HFrEF without cachexia, and 19 patients with ischaemic heart disease and preserved ejection fraction. Patients with HFrEF and cardiac cachexia displayed higher FGF-21 levels median (inter quantile range) 381 (232-577) pg/mL than patients with HFrEF without cachexia 224 (179-309) pg/mL and ischaemic heart disease patients 221 (156-308) pg/mL (P = 0.0496). No difference in MCP-1 levels were found among the groups (P = 0.345). In a multivariable regression analysis, FGF-21 (logarithm 2) was independently associated with interleukin 6 (logarithm 2) (P = 0.015) and lower muscle mass (P = 0.043), while no relation with N-terminal pro-hormone brain natriuretic peptide was observed.CONCLUSIONS: Fibroblast growth factor 21 (FGF-21) levels were elevated in patients with HFrEF and cardiac cachexia, which could be mediated by increased inflammation and muscle wasting rather than impaired cardiac function.
U2 - 10.1002/ehf2.12502
DO - 10.1002/ehf2.12502
M3 - Journal article
C2 - 31429530
VL - 6
SP - 983
EP - 991
JO - E S C Heart Failure
JF - E S C Heart Failure
SN - 2055-5822
IS - 5
ER -
ID: 241108177