Familial colorectal cancer type X: genetic profiles and phenotypic features

Research output: Contribution to journal › Review › Research › peer-review

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Familial colorectal cancer type X : genetic profiles and phenotypic features. / Dominguez-Valentin, Mev; Therkildsen, Christina; Da Silva, Sabrina; Nilbert, Mef.

In: Modern Pathology, Vol. 28, No. 1, 01.2015, p. 30-36.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Dominguez-Valentin, M, Therkildsen, C, Da Silva, S & Nilbert, M 2015, 'Familial colorectal cancer type X: genetic profiles and phenotypic features', Modern Pathology, vol. 28, no. 1, pp. 30-36. https://doi.org/10.1038/modpathol.2014.49

APA

Dominguez-Valentin, M., Therkildsen, C., Da Silva, S., & Nilbert, M. (2015). Familial colorectal cancer type X: genetic profiles and phenotypic features. Modern Pathology, 28(1), 30-36. https://doi.org/10.1038/modpathol.2014.49

Vancouver

Dominguez-Valentin M, Therkildsen C, Da Silva S, Nilbert M. Familial colorectal cancer type X: genetic profiles and phenotypic features. Modern Pathology. 2015 Jan;28(1):30-36. https://doi.org/10.1038/modpathol.2014.49

Author

Dominguez-Valentin, Mev ; Therkildsen, Christina ; Da Silva, Sabrina ; Nilbert, Mef. / Familial colorectal cancer type X : genetic profiles and phenotypic features. In: Modern Pathology. 2015 ; Vol. 28, No. 1. pp. 30-36.

Bibtex

@article{d3633640942840d9a2ccc780e01a018d,
title = "Familial colorectal cancer type X: genetic profiles and phenotypic features",
abstract = "Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.",
author = "Mev Dominguez-Valentin and Christina Therkildsen and {Da Silva}, Sabrina and Mef Nilbert",
year = "2015",
month = jan,
doi = "10.1038/modpathol.2014.49",
language = "English",
volume = "28",
pages = "30--36",
journal = "Modern Pathology",
issn = "0893-3952",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Familial colorectal cancer type X

T2 - genetic profiles and phenotypic features

AU - Dominguez-Valentin, Mev

AU - Therkildsen, Christina

AU - Da Silva, Sabrina

AU - Nilbert, Mef

PY - 2015/1

Y1 - 2015/1

N2 - Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.

AB - Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.

U2 - 10.1038/modpathol.2014.49

DO - 10.1038/modpathol.2014.49

M3 - Review

C2 - 24743215

VL - 28

SP - 30

EP - 36

JO - Modern Pathology

JF - Modern Pathology

SN - 0893-3952

IS - 1

ER -

ID: 138497946