Familial clustering of unexplained heart failure: A Danish nationwide cohort study
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Familial clustering of unexplained heart failure : A Danish nationwide cohort study. / Glinge, Charlotte; Rossetti, Sara; Oestergaard, Louise Bruun; Stampe, Niels Kjær; Jacobsen, Mia Ravn; Køber, Lars; Engstrøm, Thomas; Torp-Pedersen, Christian; Gislason, Gunnar; Jabbari, Reza; Tfelt-Hansen, Jacob.
In: International Journal of Cardiology, Vol. 407, 132028, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Familial clustering of unexplained heart failure
T2 - A Danish nationwide cohort study
AU - Glinge, Charlotte
AU - Rossetti, Sara
AU - Oestergaard, Louise Bruun
AU - Stampe, Niels Kjær
AU - Jacobsen, Mia Ravn
AU - Køber, Lars
AU - Engstrøm, Thomas
AU - Torp-Pedersen, Christian
AU - Gislason, Gunnar
AU - Jabbari, Reza
AU - Tfelt-Hansen, Jacob
N1 - Copyright © 2024. Published by Elsevier B.V.
PY - 2024
Y1 - 2024
N2 - AIMS: To determine whether a family history of unexplained heart failure (HF) in first-degree relatives (children or sibling) increases the rate of unexplained HF.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2017), we identified patients (probands) diagnosed with first unexplained HF (HF without any known comorbidities) in Denmark, and their first-degree relatives. All first-degree relatives were followed from the HF date of the proband and until an event of unexplained HF, exclusion diagnosis, death, emigration, or study end, whichever occurred first. Using the general population as a reference, we calculated adjusted standardized incidence ratios (SIR) of unexplained HF in the three groups of relatives using Poisson regression models. We identified 55,110 first-degree relatives to individuals previously diagnosed with unexplained HF. Having a family history was associated with a significantly increased unexplained HF rate of 2.59 (95%CI 2.29-2.93). The estimate was higher among siblings (SIR 6.67 [95%CI 4.69-9.48]). Noteworthy, the rate of HF increased for all first-degree relatives when the proband was diagnosed with HF in a young age (≤50 years, SIR of 7.23 [95%CI 5.40-9.68]) and having >1 proband (SIR of 5.28 [95%CI 2.75-10.14]). The highest estimate of HF was observed if the proband was ≤40 years at diagnosis (13.17 [95%CI 8.90-19.49].CONCLUSION: A family history of unexplained HF was associated with a two-fold increased rate of unexplained HF among first-degree relatives. The relative rate was increased when the proband was diagnosed at a young age. These data suggest that screening families of unexplained HF with onset below 50 years is indicated.
AB - AIMS: To determine whether a family history of unexplained heart failure (HF) in first-degree relatives (children or sibling) increases the rate of unexplained HF.METHODS AND RESULTS: Using Danish nationwide registry data (1978-2017), we identified patients (probands) diagnosed with first unexplained HF (HF without any known comorbidities) in Denmark, and their first-degree relatives. All first-degree relatives were followed from the HF date of the proband and until an event of unexplained HF, exclusion diagnosis, death, emigration, or study end, whichever occurred first. Using the general population as a reference, we calculated adjusted standardized incidence ratios (SIR) of unexplained HF in the three groups of relatives using Poisson regression models. We identified 55,110 first-degree relatives to individuals previously diagnosed with unexplained HF. Having a family history was associated with a significantly increased unexplained HF rate of 2.59 (95%CI 2.29-2.93). The estimate was higher among siblings (SIR 6.67 [95%CI 4.69-9.48]). Noteworthy, the rate of HF increased for all first-degree relatives when the proband was diagnosed with HF in a young age (≤50 years, SIR of 7.23 [95%CI 5.40-9.68]) and having >1 proband (SIR of 5.28 [95%CI 2.75-10.14]). The highest estimate of HF was observed if the proband was ≤40 years at diagnosis (13.17 [95%CI 8.90-19.49].CONCLUSION: A family history of unexplained HF was associated with a two-fold increased rate of unexplained HF among first-degree relatives. The relative rate was increased when the proband was diagnosed at a young age. These data suggest that screening families of unexplained HF with onset below 50 years is indicated.
U2 - 10.1016/j.ijcard.2024.132028
DO - 10.1016/j.ijcard.2024.132028
M3 - Journal article
C2 - 38583593
VL - 407
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
M1 - 132028
ER -
ID: 389850022