Extracellular potassium and blood flow in the post-ischemic rat brain
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Extracellular potassium and blood flow in the post-ischemic rat brain. / Hansen, Anker Jón; Gjedde, Albert; Siemkowicz, Eugeniusz.
In: Pflügers ARchiv (European Journal of Physiology), Vol. 389, No. 1, 1980, p. 1-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Extracellular potassium and blood flow in the post-ischemic rat brain
AU - Hansen, Anker Jón
AU - Gjedde, Albert
AU - Siemkowicz, Eugeniusz
PY - 1980
Y1 - 1980
N2 - The concentration of extracellular potassium, [K+]e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K+]e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K+]e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K+]e decrease. Our findings suggest that the normalization of [K+]e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na+-K+-ATPase.
AB - The concentration of extracellular potassium, [K+]e, was measured in parietal cortex and basal ganglia of rats during and after ten minutes of complete cerebral ischemia. The post-ischemic normalization of [K+]e was considerably delayed in parietal cortex compared to basal ganglia, but in both regions, [K+]e reached its normal concentration within 4 min of the end of the ischemia. Also, in both regions blood flow was elevated at the time of maximal [K+]e decrease. Our findings suggest that the normalization of [K+]e and cerebrovascular resistance after ischemia are related by positive feed-back, possibly via the stimulation of Na+-K+-ATPase.
M3 - Journal article
C2 - 7193461
VL - 389
SP - 1
EP - 7
JO - Pflügers Archiv - European Journal of Physiology
JF - Pflügers Archiv - European Journal of Physiology
SN - 0031-6768
IS - 1
ER -
ID: 14946077