Expected life years compared to the general population
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Expected life years compared to the general population. / Manevski, Damjan; Gorenjec, Nina Ruzic; Andersen, Per Kragh; Perme, Maja Pohar.
In: Biometrical Journal, Vol. 65, No. 4, 2200070, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Expected life years compared to the general population
AU - Manevski, Damjan
AU - Gorenjec, Nina Ruzic
AU - Andersen, Per Kragh
AU - Perme, Maja Pohar
PY - 2023
Y1 - 2023
N2 - For cohorts with long-term follow-up, the number of years lost due to a certain disease yields a measure with a simple and appealing interpretation. Recently, an overview of the methodology used for this goal has been published, and two measures have been proposed. In this work, we consider a third option that may be useful in settings in which the other two are inappropriate. In all three measures, the survival of the given dataset is compared to the expected survival in the general population which is calculated using external mortality tables. We thoroughly analyze the differences between the three measures, their assumptions, interpretation, and the corresponding estimators. The first measure is defined in a competing risk setting and assumes an excess hazard compared to the population, while the other two measures also allow estimation for groups that live better than the general population. In this case, the observed survival of the patients is compared to that in the population. The starting point of this comparison depends on whether the entry into the study is a hazard changing event (e.g., disease diagnosis or the age at which the inclusion criteria were met). Focusing on the newly defined life years difference measure, we study the estimation of the variance and consider the possible challenges (e.g., extrapolation) that occur in practice. We illustrate its use with a dataset of French Olympic athletes. Finally, an efficient R implementation has been developed for all three measures which make this work easily available to subsequent users.
AB - For cohorts with long-term follow-up, the number of years lost due to a certain disease yields a measure with a simple and appealing interpretation. Recently, an overview of the methodology used for this goal has been published, and two measures have been proposed. In this work, we consider a third option that may be useful in settings in which the other two are inappropriate. In all three measures, the survival of the given dataset is compared to the expected survival in the general population which is calculated using external mortality tables. We thoroughly analyze the differences between the three measures, their assumptions, interpretation, and the corresponding estimators. The first measure is defined in a competing risk setting and assumes an excess hazard compared to the population, while the other two measures also allow estimation for groups that live better than the general population. In this case, the observed survival of the patients is compared to that in the population. The starting point of this comparison depends on whether the entry into the study is a hazard changing event (e.g., disease diagnosis or the age at which the inclusion criteria were met). Focusing on the newly defined life years difference measure, we study the estimation of the variance and consider the possible challenges (e.g., extrapolation) that occur in practice. We illustrate its use with a dataset of French Olympic athletes. Finally, an efficient R implementation has been developed for all three measures which make this work easily available to subsequent users.
KW - life years lost
KW - mortality tables
KW - relative survival
KW - survival analysis
KW - EXPECTATION
KW - SURVIVAL
KW - LOST
U2 - 10.1002/bimj.202200070
DO - 10.1002/bimj.202200070
M3 - Journal article
C2 - 36786295
VL - 65
JO - Biometrical Journal
JF - Biometrical Journal
SN - 0323-3847
IS - 4
M1 - 2200070
ER -
ID: 341260752