Executive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls: The Danish High Risk and Resilience Study—VIA 7, a population-based cohort study
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Executive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls : The Danish High Risk and Resilience Study—VIA 7, a population-based cohort study. / Spang, Katrine Søborg; Ellersgaard, Ditte; Hemager, Nicoline; Christiani, Camilla Jerlang; Burton, Birgitte Klee; Greve, Aja Neergaard; Gantriis, Ditte; Ohland, Jessica; Pedersen, Marianne Giørtz; Mors, Ole; Nordentoft, Merete; Plessen, Kerstin J.; Obel, Carsten; Jepsen, Jens Richardt Møllegaard; Thorup, Anne A.E.
In: European Child and Adolescent Psychiatry, Vol. 30, No. 12, 2021, p. 1871-1884.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Executive functions in 7-year-old children of parents with schizophrenia or bipolar disorder compared with controls
T2 - The Danish High Risk and Resilience Study—VIA 7, a population-based cohort study
AU - Spang, Katrine Søborg
AU - Ellersgaard, Ditte
AU - Hemager, Nicoline
AU - Christiani, Camilla Jerlang
AU - Burton, Birgitte Klee
AU - Greve, Aja Neergaard
AU - Gantriis, Ditte
AU - Ohland, Jessica
AU - Pedersen, Marianne Giørtz
AU - Mors, Ole
AU - Nordentoft, Merete
AU - Plessen, Kerstin J.
AU - Obel, Carsten
AU - Jepsen, Jens Richardt Møllegaard
AU - Thorup, Anne A.E.
N1 - Publisher Copyright: © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021
Y1 - 2021
N2 - Cognitive impairments are strongly associated with schizophrenia (SZ) and bipolar disorder (BP) with executive functions (EF) impairments as a likely key feature. Studies of everyday behavior rated EF in young children at familial high risk of SZ (FHR-SZ) are scarce and, to our knowledge, non-existent in young children at familial high risk of BP (FHR-BP). We aimed to compare everyday behavior-rated EF of FHR-SZ, FHR-BP, and control children. A nationwide population-based cohort of 522 7-year-old children with parents diagnosed with either SZ (N = 202) or BP (N = 120) and matched controls (N = 200) were recruited using the Danish national registries. The children’s EF were assessed with the Behavior Rating Inventory of Executive Functions questionnaire rated by primary caregivers and teachers. According to primary caregiver assessments, FHR-SZ children displayed widespread EF impairments and had an odds ratio of 3.7 (2.0–6.9) of having clinically significant global EF impairments compared to controls. FHR-BP children were most severely impaired regarding EF related to emotional control and had an odds ratio of 2.5 (1.2–5.1) of clinically significant global EF impairments compared to controls. Teacher assessments were overall comparable to primary caregiver assessments but teachers rated more difficulties in the FHR-SZ group than primary caregivers. Already at age 7, children with a parental history of SZ or BP displayed significant impairments of EF in everyday-life situations. FHR-SZ children displayed widespread significant impairments of EF, whereas FHR-BP children were most severely impaired on emotional control. Clinicians should be aware of potential EF impairments in FHR children.
AB - Cognitive impairments are strongly associated with schizophrenia (SZ) and bipolar disorder (BP) with executive functions (EF) impairments as a likely key feature. Studies of everyday behavior rated EF in young children at familial high risk of SZ (FHR-SZ) are scarce and, to our knowledge, non-existent in young children at familial high risk of BP (FHR-BP). We aimed to compare everyday behavior-rated EF of FHR-SZ, FHR-BP, and control children. A nationwide population-based cohort of 522 7-year-old children with parents diagnosed with either SZ (N = 202) or BP (N = 120) and matched controls (N = 200) were recruited using the Danish national registries. The children’s EF were assessed with the Behavior Rating Inventory of Executive Functions questionnaire rated by primary caregivers and teachers. According to primary caregiver assessments, FHR-SZ children displayed widespread EF impairments and had an odds ratio of 3.7 (2.0–6.9) of having clinically significant global EF impairments compared to controls. FHR-BP children were most severely impaired regarding EF related to emotional control and had an odds ratio of 2.5 (1.2–5.1) of clinically significant global EF impairments compared to controls. Teacher assessments were overall comparable to primary caregiver assessments but teachers rated more difficulties in the FHR-SZ group than primary caregivers. Already at age 7, children with a parental history of SZ or BP displayed significant impairments of EF in everyday-life situations. FHR-SZ children displayed widespread significant impairments of EF, whereas FHR-BP children were most severely impaired on emotional control. Clinicians should be aware of potential EF impairments in FHR children.
KW - Bipolar disorder
KW - Executive function
KW - Familial high risk
KW - Schizophrenia
U2 - 10.1007/s00787-020-01650-0
DO - 10.1007/s00787-020-01650-0
M3 - Journal article
C2 - 33025076
AN - SCOPUS:85092117610
VL - 30
SP - 1871
EP - 1884
JO - European Child and Adolescent Psychiatry, Supplement
JF - European Child and Adolescent Psychiatry, Supplement
SN - 1433-5719
IS - 12
ER -
ID: 302045717