Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls : The Danish High Risk and Resilience Study VIA 7. / Krantz, Mette Falkenberg; Hjorthoj, Carsten; Ellersgaard, Ditte; Hemager, Nicoline; Christiani, Camilla; Spang, Katrine Soborg; Burton, Birgitte Klee; Gregersen, Maja; Sondergaard, Anne; Greve, Aja; Ohland, Jessica; Mortensen, Preben Bo; Plessen, Kerstin Jessica; Bliksted, Vibeke; Jepsen, Jens Richardt Mollegaard; Thorup, Anne A. E.; Mors, Ole; Nordentoft, Merete.

In: Social Psychiatry and Psychiatric Epidemiology, Vol. 58, 2023, p. 113-140.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Krantz, MF, Hjorthoj, C, Ellersgaard, D, Hemager, N, Christiani, C, Spang, KS, Burton, BK, Gregersen, M, Sondergaard, A, Greve, A, Ohland, J, Mortensen, PB, Plessen, KJ, Bliksted, V, Jepsen, JRM, Thorup, AAE, Mors, O & Nordentoft, M 2023, 'Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7', Social Psychiatry and Psychiatric Epidemiology, vol. 58, pp. 113-140. https://doi.org/10.1007/s00127-022-02338-3

APA

Krantz, M. F., Hjorthoj, C., Ellersgaard, D., Hemager, N., Christiani, C., Spang, K. S., Burton, B. K., Gregersen, M., Sondergaard, A., Greve, A., Ohland, J., Mortensen, P. B., Plessen, K. J., Bliksted, V., Jepsen, J. R. M., Thorup, A. A. E., Mors, O., & Nordentoft, M. (2023). Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7. Social Psychiatry and Psychiatric Epidemiology, 58, 113-140. https://doi.org/10.1007/s00127-022-02338-3

Vancouver

Krantz MF, Hjorthoj C, Ellersgaard D, Hemager N, Christiani C, Spang KS et al. Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7. Social Psychiatry and Psychiatric Epidemiology. 2023;58:113-140. https://doi.org/10.1007/s00127-022-02338-3

Author

Krantz, Mette Falkenberg ; Hjorthoj, Carsten ; Ellersgaard, Ditte ; Hemager, Nicoline ; Christiani, Camilla ; Spang, Katrine Soborg ; Burton, Birgitte Klee ; Gregersen, Maja ; Sondergaard, Anne ; Greve, Aja ; Ohland, Jessica ; Mortensen, Preben Bo ; Plessen, Kerstin Jessica ; Bliksted, Vibeke ; Jepsen, Jens Richardt Mollegaard ; Thorup, Anne A. E. ; Mors, Ole ; Nordentoft, Merete. / Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls : The Danish High Risk and Resilience Study VIA 7. In: Social Psychiatry and Psychiatric Epidemiology. 2023 ; Vol. 58. pp. 113-140.

Bibtex

@article{9e71eb360fad4b5ea67dbd31ff3975d5,
title = "Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7",
abstract = "Purpose Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.Methods Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.Results In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0 .04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (pConclusions Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.",
keywords = "Familial high-risk, Severe parental mental illness, Socio-economy, Representativity, Generalizability, PSYCHIATRIC-DISORDERS, METAANALYSIS, PARENTS, NEUROCOGNITION, NONRESPONSE, IMPAIRMENTS, RELIABILITY, INVENTORY, REGISTRY, VERSION",
author = "Krantz, {Mette Falkenberg} and Carsten Hjorthoj and Ditte Ellersgaard and Nicoline Hemager and Camilla Christiani and Spang, {Katrine Soborg} and Burton, {Birgitte Klee} and Maja Gregersen and Anne Sondergaard and Aja Greve and Jessica Ohland and Mortensen, {Preben Bo} and Plessen, {Kerstin Jessica} and Vibeke Bliksted and Jepsen, {Jens Richardt Mollegaard} and Thorup, {Anne A. E.} and Ole Mors and Merete Nordentoft",
year = "2023",
doi = "10.1007/s00127-022-02338-3",
language = "English",
volume = "58",
pages = "113--140",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "Springer Medizin",

}

RIS

TY - JOUR

T1 - Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls

T2 - The Danish High Risk and Resilience Study VIA 7

AU - Krantz, Mette Falkenberg

AU - Hjorthoj, Carsten

AU - Ellersgaard, Ditte

AU - Hemager, Nicoline

AU - Christiani, Camilla

AU - Spang, Katrine Soborg

AU - Burton, Birgitte Klee

AU - Gregersen, Maja

AU - Sondergaard, Anne

AU - Greve, Aja

AU - Ohland, Jessica

AU - Mortensen, Preben Bo

AU - Plessen, Kerstin Jessica

AU - Bliksted, Vibeke

AU - Jepsen, Jens Richardt Mollegaard

AU - Thorup, Anne A. E.

AU - Mors, Ole

AU - Nordentoft, Merete

PY - 2023

Y1 - 2023

N2 - Purpose Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.Methods Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.Results In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0 .04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (pConclusions Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.

AB - Purpose Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.Methods Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.Results In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0 .04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (pConclusions Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.

KW - Familial high-risk

KW - Severe parental mental illness

KW - Socio-economy

KW - Representativity

KW - Generalizability

KW - PSYCHIATRIC-DISORDERS

KW - METAANALYSIS

KW - PARENTS

KW - NEUROCOGNITION

KW - NONRESPONSE

KW - IMPAIRMENTS

KW - RELIABILITY

KW - INVENTORY

KW - REGISTRY

KW - VERSION

U2 - 10.1007/s00127-022-02338-3

DO - 10.1007/s00127-022-02338-3

M3 - Journal article

C2 - 36087138

VL - 58

SP - 113

EP - 140

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

SN - 0933-7954

ER -

ID: 319650057