Evidence for a mediator cycle at the initiation of transcription

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Evidence for a mediator cycle at the initiation of transcription. / Svejstrup, Jesper Q.; Li, Yang; Fellows, Jane; Gnatt, Averell; Bjorklund, Stefan; Kornberg, Roger D.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 12, 10.06.1997, p. 6075-6078.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Svejstrup, JQ, Li, Y, Fellows, J, Gnatt, A, Bjorklund, S & Kornberg, RD 1997, 'Evidence for a mediator cycle at the initiation of transcription', Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 12, pp. 6075-6078. https://doi.org/10.1073/pnas.94.12.6075

APA

Svejstrup, J. Q., Li, Y., Fellows, J., Gnatt, A., Bjorklund, S., & Kornberg, R. D. (1997). Evidence for a mediator cycle at the initiation of transcription. Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6075-6078. https://doi.org/10.1073/pnas.94.12.6075

Vancouver

Svejstrup JQ, Li Y, Fellows J, Gnatt A, Bjorklund S, Kornberg RD. Evidence for a mediator cycle at the initiation of transcription. Proceedings of the National Academy of Sciences of the United States of America. 1997 Jun 10;94(12):6075-6078. https://doi.org/10.1073/pnas.94.12.6075

Author

Svejstrup, Jesper Q. ; Li, Yang ; Fellows, Jane ; Gnatt, Averell ; Bjorklund, Stefan ; Kornberg, Roger D. / Evidence for a mediator cycle at the initiation of transcription. In: Proceedings of the National Academy of Sciences of the United States of America. 1997 ; Vol. 94, No. 12. pp. 6075-6078.

Bibtex

@article{590cde452ef445c2b26d487464acfc80,
title = "Evidence for a mediator cycle at the initiation of transcription",
abstract = "Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C- terminal domain phosphorylation.",
keywords = "C-terminal domain, RNA polymerase II, Yeast",
author = "Svejstrup, {Jesper Q.} and Yang Li and Jane Fellows and Averell Gnatt and Stefan Bjorklund and Kornberg, {Roger D.}",
year = "1997",
month = jun,
day = "10",
doi = "10.1073/pnas.94.12.6075",
language = "English",
volume = "94",
pages = "6075--6078",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "12",

}

RIS

TY - JOUR

T1 - Evidence for a mediator cycle at the initiation of transcription

AU - Svejstrup, Jesper Q.

AU - Li, Yang

AU - Fellows, Jane

AU - Gnatt, Averell

AU - Bjorklund, Stefan

AU - Kornberg, Roger D.

PY - 1997/6/10

Y1 - 1997/6/10

N2 - Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C- terminal domain phosphorylation.

AB - Free and elongating (DNA-bound) forms of RNA polymerase II were separated from yeast. Most cellular polymerase II was found in the elongating fraction, which contained all enzyme phosphorylated on the C-terminal domain and none of the 15-subunit mediator of transcriptional regulation. These and other findings suggest that mediator enters and leaves initiation complexes during every round of transcription, in a process that may be coupled to C- terminal domain phosphorylation.

KW - C-terminal domain

KW - RNA polymerase II

KW - Yeast

U2 - 10.1073/pnas.94.12.6075

DO - 10.1073/pnas.94.12.6075

M3 - Journal article

C2 - 9177171

AN - SCOPUS:0030947346

VL - 94

SP - 6075

EP - 6078

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 12

ER -

ID: 331574765