Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses
Research output: Contribution to journal › Journal article › Research › peer-review
OBJECTIVE: To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses.
ANIMALS: 9 healthy adult horses.
PROCEDURES: Each horse received 4 treatments in a blinded, randomized, crossover study design as follows: TMS, 16 to 24 mg/kg, IV; DET, 0.015 to 0.02 mg/kg, IV; TMS plus DET; and saline (0.9% NaCl) solution. Surface ECG traces were obtained over 24 hours, and repolarization parameters were measured at predefined time points after each treatment and compared with a 2-way ANOVA for repeated measures.
RESULTS: Heart rate-corrected QT intervals (QTc) were significantly increased after administration of DET (mean ± SD difference in QTc, 36.57 ± 23.07 milliseconds; increase of 7%) and TMS plus DET (44.96 ± 29.16 milliseconds; increase of 9%), compared with baseline (before treatment) values and values after administration of saline solution. Saline solution and TMS alone did not affect QTc.
CONCLUSIONS AND CLINICAL RELEVANCE: Administration of DET or TMS plus DET was associated with a significant and possibly clinically relevant prolongation of QTc, with prolongation of 7% to 9%, a range that is considered as a risk factor for the development of cardiac arrhythmias in people. Results were unexpected because DET is considered to be a safe sedative for horses.
Original language | English |
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Journal | American Journal of Veterinary Research |
Volume | 82 |
Issue number | 3 |
Pages (from-to) | 207-217 |
Number of pages | 11 |
ISSN | 0002-9645 |
DOIs | |
Publication status | Published - 2021 |
- Animals, Cross-Over Studies, Electrocardiography/veterinary, Heart Rate, Horses, Imidazoles, Sulfadiazine, Trimethoprim/adverse effects
Research areas
ID: 258229335