TY - JOUR

T1 - Evaluating the Contribution of the Cause of Kidney Disease to Prognosis in CKD

T2 - Results From the Study of Heart and Renal Protection (SHARP)

AU - Haynes, Richard

AU - Staplin, Natalie

AU - Emberson, Jonathan

AU - Herrington, William G

AU - Tomson, Charles

AU - Agodoa, Lawrence

AU - Tesar, Vladimir

AU - Levin, Adeera

AU - Lewis, David

AU - Reith, Christina

AU - Baigent, Colin

AU - Landray, Martin J

AU - SHARP Collaborative Group

AU - Feldt-Rasmussen, Bo

N1 - Copyright © 2014 National Kidney Foundation, Inc. All rights reserved.

PY - 2014/7

Y1 - 2014/7

N2 - BACKGROUND: The relevance of the cause of kidney disease to prognosis among patients with chronic kidney disease is uncertain.STUDY DESIGN: Observational study.SETTINGS & PARTICIPANTS: 6,245 nondialysis participants in the Study of Heart and Renal Protection (SHARP).PREDICTOR: Baseline cause of kidney disease was categorized into 4 groups: cystic kidney disease, diabetic nephropathy, glomerulonephritis, and other recorded diagnoses.OUTCOMES: End-stage renal disease (ESRD; dialysis or transplantation) and death.RESULTS: During an average 4.7 years' follow-up, 2,080 participants progressed to ESRD, including 454 with cystic kidney disease (23% per year), 378 with glomerulonephritis (10% per year), 309 with diabetic nephropathy (12% per year), and 939 with other recorded diagnoses (8% per year). By comparison with patients with cystic kidney disease, other disease groups had substantially lower adjusted risks of ESRD (relative risks of 0.28 [95% CI, 0.24-0.32], 0.40 [95% CI, 0.34-0.47], and 0.29 [95% CI, 0.25-0.32] for glomerulonephritis, diabetic nephropathy, and other recorded diagnoses, respectively). Albuminuria and baseline estimated glomerular filtration rate were associated more weakly with risk of ESRD in patients with cystic kidney disease than the 3 other diagnostic categories (P for interaction, <0.001 and 0.01, respectively). Death before ESRD was uncommon in patients with cystic kidney disease, but was a major competing risk for participants with diabetic nephropathy, whose adjusted risk of death was 2-fold higher than that of the cystic kidney disease group (relative risk, 2.35 [95% CI, 1.73-3.18]).LIMITATIONS: Exclusion of patients with prior myocardial infarction or coronary revascularization.CONCLUSIONS: The cause of kidney disease has substantial prognostic implications. Other things being equal, patients with cystic kidney disease are at much higher risk of ESRD (and much lower risk of death before ESRD) than other patients. Patients with diabetic nephropathy are at particularly high risk of death prior to reaching ESRD.

AB - BACKGROUND: The relevance of the cause of kidney disease to prognosis among patients with chronic kidney disease is uncertain.STUDY DESIGN: Observational study.SETTINGS & PARTICIPANTS: 6,245 nondialysis participants in the Study of Heart and Renal Protection (SHARP).PREDICTOR: Baseline cause of kidney disease was categorized into 4 groups: cystic kidney disease, diabetic nephropathy, glomerulonephritis, and other recorded diagnoses.OUTCOMES: End-stage renal disease (ESRD; dialysis or transplantation) and death.RESULTS: During an average 4.7 years' follow-up, 2,080 participants progressed to ESRD, including 454 with cystic kidney disease (23% per year), 378 with glomerulonephritis (10% per year), 309 with diabetic nephropathy (12% per year), and 939 with other recorded diagnoses (8% per year). By comparison with patients with cystic kidney disease, other disease groups had substantially lower adjusted risks of ESRD (relative risks of 0.28 [95% CI, 0.24-0.32], 0.40 [95% CI, 0.34-0.47], and 0.29 [95% CI, 0.25-0.32] for glomerulonephritis, diabetic nephropathy, and other recorded diagnoses, respectively). Albuminuria and baseline estimated glomerular filtration rate were associated more weakly with risk of ESRD in patients with cystic kidney disease than the 3 other diagnostic categories (P for interaction, <0.001 and 0.01, respectively). Death before ESRD was uncommon in patients with cystic kidney disease, but was a major competing risk for participants with diabetic nephropathy, whose adjusted risk of death was 2-fold higher than that of the cystic kidney disease group (relative risk, 2.35 [95% CI, 1.73-3.18]).LIMITATIONS: Exclusion of patients with prior myocardial infarction or coronary revascularization.CONCLUSIONS: The cause of kidney disease has substantial prognostic implications. Other things being equal, patients with cystic kidney disease are at much higher risk of ESRD (and much lower risk of death before ESRD) than other patients. Patients with diabetic nephropathy are at particularly high risk of death prior to reaching ESRD.

KW - Aged

KW - Diabetic Nephropathies

KW - Female

KW - Follow-Up Studies

KW - Glomerular Filtration Rate

KW - Glomerulonephritis

KW - Humans

KW - Kidney Diseases, Cystic

KW - Kidney Failure, Chronic

KW - Kidney Transplantation

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Renal Dialysis

KW - Renal Insufficiency, Chronic

KW - Risk Factors

KW - Survival Rate

U2 - 10.1053/j.ajkd.2013.12.013

DO - 10.1053/j.ajkd.2013.12.013

M3 - Journal article

C2 - 24613056

VL - 64

SP - 40

EP - 48

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 1

ER -