Evaluating risk factors in recurrent pregnancy loss: A prospective cohort study and its impact on live birth outcomes
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Evaluating risk factors in recurrent pregnancy loss : A prospective cohort study and its impact on live birth outcomes. / Nielsen, Josefine Reinhardt; Kolte, Astrid Marie; Bliddal, Sofie; Jørgensen, Henrik Løvendahl; Johnsen, Morten Guldborg; Krog, Maria Christine; Westergaard, David; Nielsen, Henriette Svarre.
In: Journal of Reproductive Immunology, Vol. 165, 104297, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Evaluating risk factors in recurrent pregnancy loss
T2 - A prospective cohort study and its impact on live birth outcomes
AU - Nielsen, Josefine Reinhardt
AU - Kolte, Astrid Marie
AU - Bliddal, Sofie
AU - Jørgensen, Henrik Løvendahl
AU - Johnsen, Morten Guldborg
AU - Krog, Maria Christine
AU - Westergaard, David
AU - Nielsen, Henriette Svarre
N1 - Publisher Copyright: © 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Recurrent pregnancy loss (RPL) affects 1–2 % of all couples trying to conceive and is a challenging heterogeneous condition. This study aimed to evaluate the prevalence and impact of various risk factors in patients suffering from RPL. We performed a prospective cohort study including patients at the tertiary RPL Unit in the Capital Region of Denmark between 1st January 2000 and 1st January 2023. The main outcome of the study was the first pregnancy after referral and whether the pregnancy was ongoing at least to the 22nd gestational week. A total of 2555 patients were included in the study, out of whom 1892 patients achieved a pregnancy after referral to the RPL Unit. This resulted in 1103 live births (58.3 %) and 718 pregnancy losses (37.9 %). Maternal age, BMI, smoking status and the number of prior pregnancy losses were negatively correlated with the likelihood of achieving pregnancy. Furthermore, maternal age, prior pregnancy losses, antiphospholipid syndrome (APS) and uterine malformations were associated with reduced birth rates. Patients with secondary RPL had a higher birth rate compared to those with primary RPL, and patients with APS treated with low-molecular-weight heparin (LMWH) demonstrated a significantly increased birth rate compared to untreated APS patients. These findings suggest that certain risk factors significantly impact the likelihood of achieving pregnancy and live birth following RPL, which can be used in patient guidance.
AB - Recurrent pregnancy loss (RPL) affects 1–2 % of all couples trying to conceive and is a challenging heterogeneous condition. This study aimed to evaluate the prevalence and impact of various risk factors in patients suffering from RPL. We performed a prospective cohort study including patients at the tertiary RPL Unit in the Capital Region of Denmark between 1st January 2000 and 1st January 2023. The main outcome of the study was the first pregnancy after referral and whether the pregnancy was ongoing at least to the 22nd gestational week. A total of 2555 patients were included in the study, out of whom 1892 patients achieved a pregnancy after referral to the RPL Unit. This resulted in 1103 live births (58.3 %) and 718 pregnancy losses (37.9 %). Maternal age, BMI, smoking status and the number of prior pregnancy losses were negatively correlated with the likelihood of achieving pregnancy. Furthermore, maternal age, prior pregnancy losses, antiphospholipid syndrome (APS) and uterine malformations were associated with reduced birth rates. Patients with secondary RPL had a higher birth rate compared to those with primary RPL, and patients with APS treated with low-molecular-weight heparin (LMWH) demonstrated a significantly increased birth rate compared to untreated APS patients. These findings suggest that certain risk factors significantly impact the likelihood of achieving pregnancy and live birth following RPL, which can be used in patient guidance.
KW - Cohort study
KW - Live birth
KW - Pregnancy
KW - Recurrent pregnancy loss
KW - Risk factors
U2 - 10.1016/j.jri.2024.104297
DO - 10.1016/j.jri.2024.104297
M3 - Journal article
C2 - 39029322
AN - SCOPUS:85198565004
VL - 165
JO - Journal of Reproductive Immunology
JF - Journal of Reproductive Immunology
SN - 0165-0378
M1 - 104297
ER -
ID: 399026293