Esterase activity in the guinea pig thyroid under normal and pathological conditions (vitamin A deficiency) with special regard to cyst-like structures
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Esterase activity in the guinea pig thyroid under normal and pathological conditions (vitamin A deficiency) with special regard to cyst-like structures. / Kirkeby, Svend.
In: Virchows Archiv B Cell Pathology Including Molecular Pathology, Vol. 23, No. 2, 1977, p. 129-136.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Esterase activity in the guinea pig thyroid under normal and pathological conditions (vitamin A deficiency) with special regard to cyst-like structures
AU - Kirkeby, Svend
N1 - Keywords: Animals; Cysts; Epithelial Cells; Epithelium; Esterases; Guinea Pigs; Histocytochemistry; Thyroid Diseases; Thyroid Gland; Vitamin A Deficiency
PY - 1977
Y1 - 1977
N2 - By use of different activators and inhibitors, TOCP(tri-o-cresyl phosphate), PCMB (parachloromercury benzoate), NiCl2, Pb(NO3)2, HgCl2, Hg(NO3)2, eserine and sodium taurocholate, it is shown that the esterase in the cyst cells and in group I cells of the guinea pig thyroid probably are A-esterase isoenzymes. The activity in the majority of cyst cells is considerably stronger than in the other thyroid epithelial cells, and it is resistant to Hg inactivation. Neither esterase type nor intensity of the reaction product is altered in group I-II or cyst cells during vitamin A-deficiency. When a normal diet is given, the esterase in all thyroid epithelial cells is very sensitive to sodium taurocholate, while in cyst cells it is rather resistant to this inhibitor at vitamin-A-deficiency.
AB - By use of different activators and inhibitors, TOCP(tri-o-cresyl phosphate), PCMB (parachloromercury benzoate), NiCl2, Pb(NO3)2, HgCl2, Hg(NO3)2, eserine and sodium taurocholate, it is shown that the esterase in the cyst cells and in group I cells of the guinea pig thyroid probably are A-esterase isoenzymes. The activity in the majority of cyst cells is considerably stronger than in the other thyroid epithelial cells, and it is resistant to Hg inactivation. Neither esterase type nor intensity of the reaction product is altered in group I-II or cyst cells during vitamin A-deficiency. When a normal diet is given, the esterase in all thyroid epithelial cells is very sensitive to sodium taurocholate, while in cyst cells it is rather resistant to this inhibitor at vitamin-A-deficiency.
U2 - 10.1007/BF02889125
DO - 10.1007/BF02889125
M3 - Journal article
C2 - 402738
VL - 23
SP - 129
EP - 136
JO - Virchows Archiv B Cell Pathology Including Molecular Pathology
JF - Virchows Archiv B Cell Pathology Including Molecular Pathology
SN - 0042-6431
IS - 2
ER -
ID: 10252599