Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria's experience

Research output: Contribution to journal › Review › Research › peer-review

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Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework : Nigeria's experience. / Okeke, Iruka N; Aboderin, Aaron O; Egwuenu, Abiodun; Underwood, Anthony; Afolayan, Ayorinde O; Kekre, Mihir; Oaikhena, Anderson O; Odih, Erkison Ewomazino; Omotayo, Hamzat T; Dada-Adegbola, Hannah; Ogunleye, Veronica O; Ikhimiukor, Odion O; Aanensen, David M; Ihekweazu, Chikwe.

In: Microbiology, Vol. 168, No. 8, 001208, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Okeke, IN, Aboderin, AO, Egwuenu, A, Underwood, A, Afolayan, AO, Kekre, M, Oaikhena, AO, Odih, EE, Omotayo, HT, Dada-Adegbola, H, Ogunleye, VO, Ikhimiukor, OO, Aanensen, DM & Ihekweazu, C 2022, 'Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria's experience', Microbiology, vol. 168, no. 8, 001208. https://doi.org/10.1099/mic.0.001208

APA

Okeke, I. N., Aboderin, A. O., Egwuenu, A., Underwood, A., Afolayan, A. O., Kekre, M., Oaikhena, A. O., Odih, E. E., Omotayo, H. T., Dada-Adegbola, H., Ogunleye, V. O., Ikhimiukor, O. O., Aanensen, D. M., & Ihekweazu, C. (2022). Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria's experience. Microbiology, 168(8), [001208]. https://doi.org/10.1099/mic.0.001208

Vancouver

Okeke IN, Aboderin AO, Egwuenu A, Underwood A, Afolayan AO, Kekre M et al. Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria's experience. Microbiology. 2022;168(8). 001208. https://doi.org/10.1099/mic.0.001208

Author

Okeke, Iruka N ; Aboderin, Aaron O ; Egwuenu, Abiodun ; Underwood, Anthony ; Afolayan, Ayorinde O ; Kekre, Mihir ; Oaikhena, Anderson O ; Odih, Erkison Ewomazino ; Omotayo, Hamzat T ; Dada-Adegbola, Hannah ; Ogunleye, Veronica O ; Ikhimiukor, Odion O ; Aanensen, David M ; Ihekweazu, Chikwe. / Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework : Nigeria's experience. In: Microbiology. 2022 ; Vol. 168, No. 8.

Bibtex

@article{d41c80c5caa24367bfc04b1458170636,
title = "Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework: Nigeria's experience",
abstract = "Whole-genome sequencing (WGS) is finding important applications in the surveillance of antimicrobial resistance (AMR), providing the most granular data and broadening the scope of niches and locations that can be surveilled. A common but often overlooked application of WGS is to replace or augment reference laboratory services for AMR surveillance. WGS has supplanted traditional strain subtyping in many comprehensive reference laboratories and is now the gold standard for rapidly ruling isolates into or out of suspected outbreak clusters. These and other properties give WGS the potential to serve in AMR reference functioning where a reference laboratory did not hitherto exist. In this perspective, we describe how we have employed a WGS approach, and an academic-public health system collaboration, to provide AMR reference laboratory services in Nigeria, as a model for leapfrogging to national AMR surveillance.",
keywords = "Anti-Bacterial Agents/pharmacology, Disease Outbreaks, Drug Resistance, Bacterial/genetics, Nigeria, Whole Genome Sequencing",
author = "Okeke, {Iruka N} and Aboderin, {Aaron O} and Abiodun Egwuenu and Anthony Underwood and Afolayan, {Ayorinde O} and Mihir Kekre and Oaikhena, {Anderson O} and Odih, {Erkison Ewomazino} and Omotayo, {Hamzat T} and Hannah Dada-Adegbola and Ogunleye, {Veronica O} and Ikhimiukor, {Odion O} and Aanensen, {David M} and Chikwe Ihekweazu",
year = "2022",
doi = "10.1099/mic.0.001208",
language = "English",
volume = "168",
journal = "Microbiology",
issn = "1350-0872",
publisher = "Society for General Microbiology",
number = "8",

}

RIS

TY - JOUR

T1 - Establishing a national reference laboratory for antimicrobial resistance using a whole-genome sequencing framework

T2 - Nigeria's experience

AU - Okeke, Iruka N

AU - Aboderin, Aaron O

AU - Egwuenu, Abiodun

AU - Underwood, Anthony

AU - Afolayan, Ayorinde O

AU - Kekre, Mihir

AU - Oaikhena, Anderson O

AU - Odih, Erkison Ewomazino

AU - Omotayo, Hamzat T

AU - Dada-Adegbola, Hannah

AU - Ogunleye, Veronica O

AU - Ikhimiukor, Odion O

AU - Aanensen, David M

AU - Ihekweazu, Chikwe

PY - 2022

Y1 - 2022

N2 - Whole-genome sequencing (WGS) is finding important applications in the surveillance of antimicrobial resistance (AMR), providing the most granular data and broadening the scope of niches and locations that can be surveilled. A common but often overlooked application of WGS is to replace or augment reference laboratory services for AMR surveillance. WGS has supplanted traditional strain subtyping in many comprehensive reference laboratories and is now the gold standard for rapidly ruling isolates into or out of suspected outbreak clusters. These and other properties give WGS the potential to serve in AMR reference functioning where a reference laboratory did not hitherto exist. In this perspective, we describe how we have employed a WGS approach, and an academic-public health system collaboration, to provide AMR reference laboratory services in Nigeria, as a model for leapfrogging to national AMR surveillance.

AB - Whole-genome sequencing (WGS) is finding important applications in the surveillance of antimicrobial resistance (AMR), providing the most granular data and broadening the scope of niches and locations that can be surveilled. A common but often overlooked application of WGS is to replace or augment reference laboratory services for AMR surveillance. WGS has supplanted traditional strain subtyping in many comprehensive reference laboratories and is now the gold standard for rapidly ruling isolates into or out of suspected outbreak clusters. These and other properties give WGS the potential to serve in AMR reference functioning where a reference laboratory did not hitherto exist. In this perspective, we describe how we have employed a WGS approach, and an academic-public health system collaboration, to provide AMR reference laboratory services in Nigeria, as a model for leapfrogging to national AMR surveillance.

KW - Anti-Bacterial Agents/pharmacology

KW - Disease Outbreaks

KW - Drug Resistance, Bacterial/genetics

KW - Nigeria

KW - Whole Genome Sequencing

U2 - 10.1099/mic.0.001208

DO - 10.1099/mic.0.001208

M3 - Review

C2 - 35980376

VL - 168

JO - Microbiology

JF - Microbiology

SN - 1350-0872

IS - 8

M1 - 001208

ER -

ID: 337998990