Endocrine therapy of human breast cancer grown in nude mice
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Endocrine therapy of human breast cancer grown in nude mice. / Brünner, N; Osborne, C K; Spang-Thomsen, M.
In: Breast Cancer Research and Treatment, Vol. 10, No. 3, 1987, p. 229-42.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Endocrine therapy of human breast cancer grown in nude mice
AU - Brünner, N
AU - Osborne, C K
AU - Spang-Thomsen, M
N1 - Keywords: Animals; Breast Neoplasms; Disease Models, Animal; Female; Flow Cytometry; Hormones; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Transplantation, Heterologous
PY - 1987
Y1 - 1987
N2 - Although there have been extensive studies of rodent breast tumor models, and of human breast cancer cell lines in culture, there is still need for a human tumor model which can be manipulated experimentally but also provides a valid expression of the tumor cells in a host environment. Athymic nude mice bearing transplanted human breast tumors have been proposed as such a model. This review therefore discusses the use of the athymic nude mouse model of the study of human breast cancer biology, and focuses on four subjects: 1. biological characteristics of heterotransplanted breast tumors; 2. endocrinology and pharmacology of hormonal agents in the nude mouse; 3. endocrine sensitivity of heterotransplanted tumors; and 4. applicability and limitations of this model for the study of human breast cancer.
AB - Although there have been extensive studies of rodent breast tumor models, and of human breast cancer cell lines in culture, there is still need for a human tumor model which can be manipulated experimentally but also provides a valid expression of the tumor cells in a host environment. Athymic nude mice bearing transplanted human breast tumors have been proposed as such a model. This review therefore discusses the use of the athymic nude mouse model of the study of human breast cancer biology, and focuses on four subjects: 1. biological characteristics of heterotransplanted breast tumors; 2. endocrinology and pharmacology of hormonal agents in the nude mouse; 3. endocrine sensitivity of heterotransplanted tumors; and 4. applicability and limitations of this model for the study of human breast cancer.
M3 - Journal article
C2 - 3328985
VL - 10
SP - 229
EP - 242
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 3
ER -
ID: 12871033