Elongator complex: how many roles does it play?
Research output: Contribution to journal › Review › Research › peer-review
The multi-subunit Elongator complex was first identified by its association with an RNA polymerase II holoenzyme engaged in transcriptional elongation, and subsequent data have provided further evidence that the complex is involved in histone acetylation and transcription. However, most Elongator is cytoplasmic, and recent data has indicated a role in processes as diverse as exocytosis and tRNA modification. One of the subunits of Elongator is encoded by a gene that is mutated in patients suffering from the severe neurodevelopmental disorder familial dysautonomia.
Original language | English |
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Journal | Current Opinion in Cell Biology |
Volume | 19 |
Issue number | 3 |
Pages (from-to) | 331-336 |
Number of pages | 6 |
ISSN | 0955-0674 |
DOIs | |
Publication status | Published - Jun 2007 |
Externally published | Yes |
Bibliographical note
Funding Information:
Work in the author's laboratory is supported by a generous grant from Cancer Research UK. A Barbara Dirac-Svejstrup, Luke Selth, and Pierre Close are thanked for helpful suggestions on the manuscript.
ID: 331024101