Elongator complex: how many roles does it play?
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Elongator complex : how many roles does it play? / Svejstrup, Jesper Q.
In: Current Opinion in Cell Biology, Vol. 19, No. 3, 06.2007, p. 331-336.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Elongator complex
T2 - how many roles does it play?
AU - Svejstrup, Jesper Q.
N1 - Funding Information: Work in the author's laboratory is supported by a generous grant from Cancer Research UK. A Barbara Dirac-Svejstrup, Luke Selth, and Pierre Close are thanked for helpful suggestions on the manuscript.
PY - 2007/6
Y1 - 2007/6
N2 - The multi-subunit Elongator complex was first identified by its association with an RNA polymerase II holoenzyme engaged in transcriptional elongation, and subsequent data have provided further evidence that the complex is involved in histone acetylation and transcription. However, most Elongator is cytoplasmic, and recent data has indicated a role in processes as diverse as exocytosis and tRNA modification. One of the subunits of Elongator is encoded by a gene that is mutated in patients suffering from the severe neurodevelopmental disorder familial dysautonomia.
AB - The multi-subunit Elongator complex was first identified by its association with an RNA polymerase II holoenzyme engaged in transcriptional elongation, and subsequent data have provided further evidence that the complex is involved in histone acetylation and transcription. However, most Elongator is cytoplasmic, and recent data has indicated a role in processes as diverse as exocytosis and tRNA modification. One of the subunits of Elongator is encoded by a gene that is mutated in patients suffering from the severe neurodevelopmental disorder familial dysautonomia.
U2 - 10.1016/j.ceb.2007.04.005
DO - 10.1016/j.ceb.2007.04.005
M3 - Review
C2 - 17466506
AN - SCOPUS:34250305505
VL - 19
SP - 331
EP - 336
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
SN - 0955-0674
IS - 3
ER -
ID: 331024101