Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653
Research output: Patent
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Efficient cell culture system for hepatitis C virus genotype 2B : Patent #: 8,663,653 . / Gottwein, Judith Margarete (Inventor); Knudsen, Maria Lisa (Inventor); Scheel, Troels Kasper Hoyer (Inventor); Bukh, Jens (Inventor).
Patent No.: WO2010/017818. Mar 31, 2014.Research output: Patent
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TY - PAT
T1 - Efficient cell culture system for hepatitis C virus genotype 2B
T2 - Patent #: 8,663,653
AU - Gottwein, Judith Margarete
AU - Knudsen, Maria Lisa
AU - Scheel, Troels Kasper Hoyer
AU - Bukh, Jens
PY - 2014/3/31
Y1 - 2014/3/31
N2 - The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.
AB - The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.
M3 - Patent
M1 - WO2010/017818
Y2 - 2010/02/18
ER -
ID: 140392319