Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes
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Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes. / Johansen, Nicklas J.; Dejgaard, Thomas F; Lund, Asger; Schlüntz, Camilla; Hartmann, Bolette; Holst, Jens J; Vilsbøll, Tina; Andersen, Henrik U.; Knop, Filip K.
In: Diabetes, Obesity and Metabolism, Vol. 24, No. 2, 2022, p. 221-227.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of short-acting exenatide added three times daily to insulin therapy on bone metabolism in type 1 diabetes
AU - Johansen, Nicklas J.
AU - Dejgaard, Thomas F
AU - Lund, Asger
AU - Schlüntz, Camilla
AU - Hartmann, Bolette
AU - Holst, Jens J
AU - Vilsbøll, Tina
AU - Andersen, Henrik U.
AU - Knop, Filip K
N1 - This article is protected by copyright. All rights reserved.
PY - 2022
Y1 - 2022
N2 - AIMS: Glucagon-like peptide 1 (GLP-1) receptor agonists induce body weight loss, and body weight loss may reduce bone mineral density. An antiresorptive potential of long-acting GLP-1 receptor agonists has been observed in both type 1 and type 2 diabetes, but the effects of short-acting GLP-1 receptor agonism on bone metabolism have never been investigated in type 1 diabetes. The MAG1C trial evaluated the efficacy of short-acting exenatide added to insulin therapy in type 1 diabetes on bone mineral density and bone turnover markers as prespecified, secondary endpoints.MATERIALS AND METHODS: In a randomized, double-blinded, parallel-group trial, 108 individuals with type 1 diabetes aged ≥18 years on basal-bolus therapy with HbA1c 59-88 mmol/mol (7.5-10.0%) and body mass index >22.0 kg/m2 were randomized (1:1) to preprandial subcutaneous injection of 10 μg exenatide (Byetta®) before breakfast, lunch and dinner over 26 weeks as add-on treatment to regular insulin therapy.RESULTS: Exenatide elicited a 4.4 kg body weight reduction compared with placebo, but no between-group differences in bone mineral density as assessed by whole-body, hip, lumbar and forearm dual-energy X-ray absorptiometry following 26 weeks' treatment were observed. Fasting plasma levels of C-terminal telopeptides of type I collagen, a marker of bone resorption, and amino-terminal propeptide of type I procollagen, a marker of bone formation, were unchanged by exenatide compared with placebo after 26 weeks.CONCLUSIONS: Despite an exenatide-induced body weight reduction, no changes in bone metabolism were observed with exenatide added to insulin therapy in type 1 diabetes after 26 weeks. This article is protected by copyright. All rights reserved.
AB - AIMS: Glucagon-like peptide 1 (GLP-1) receptor agonists induce body weight loss, and body weight loss may reduce bone mineral density. An antiresorptive potential of long-acting GLP-1 receptor agonists has been observed in both type 1 and type 2 diabetes, but the effects of short-acting GLP-1 receptor agonism on bone metabolism have never been investigated in type 1 diabetes. The MAG1C trial evaluated the efficacy of short-acting exenatide added to insulin therapy in type 1 diabetes on bone mineral density and bone turnover markers as prespecified, secondary endpoints.MATERIALS AND METHODS: In a randomized, double-blinded, parallel-group trial, 108 individuals with type 1 diabetes aged ≥18 years on basal-bolus therapy with HbA1c 59-88 mmol/mol (7.5-10.0%) and body mass index >22.0 kg/m2 were randomized (1:1) to preprandial subcutaneous injection of 10 μg exenatide (Byetta®) before breakfast, lunch and dinner over 26 weeks as add-on treatment to regular insulin therapy.RESULTS: Exenatide elicited a 4.4 kg body weight reduction compared with placebo, but no between-group differences in bone mineral density as assessed by whole-body, hip, lumbar and forearm dual-energy X-ray absorptiometry following 26 weeks' treatment were observed. Fasting plasma levels of C-terminal telopeptides of type I collagen, a marker of bone resorption, and amino-terminal propeptide of type I procollagen, a marker of bone formation, were unchanged by exenatide compared with placebo after 26 weeks.CONCLUSIONS: Despite an exenatide-induced body weight reduction, no changes in bone metabolism were observed with exenatide added to insulin therapy in type 1 diabetes after 26 weeks. This article is protected by copyright. All rights reserved.
U2 - 10.1111/dom.14568
DO - 10.1111/dom.14568
M3 - Journal article
C2 - 34617375
VL - 24
SP - 221
EP - 227
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 2
ER -
ID: 282188687