Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. / Mitchell, Sarah J.; Madrigal-Matute, Julio; Scheibye-Knudsen, Morten; Fang, Evandro; Aon, Miguel; Gonzalez-Reyes, Jose A.; Cortassa, Sonia; Kaushik, Susmita; Gonzalez-Freire, Marta; Patel, Bindi; Wahl, Devin; Ali, Ahmed; Calvo-Rubio, Miguel; Buron, Maria I.; Guiterrez, Vincent; Ward, Theresa M.; Palacios, Hector H.; Cai, Huan; Frederick, David W.; Hine, Christopher; Broeskamp, Filomena; Habering, Lukas; Dawson, John; Beasley, T. Mark; Wan, Junxiang; Ikeno, Yuji; Hubbard, Gene; Becker, Kevin G.; Zhang, Yongqing; Bohr, Vilhelm A.; Longo, Dan L.; Navas, Placido; Ferrucci, Luigi; Sinclair, David A.; Cohen, Pinchas; Egan, Josephine M.; Mitchell, James R.; Baur, Joseph A.; Allison, David B.; Anson, R. Michael; Villalba, Jose M.; Madeo, Frank; Cuervo, Ana Maria; Pearson, Kevin J.; Ingram, Donald K.; Bernier, Michel; de Cabo, Rafael.
In: Cell Metabolism, Vol. 23, No. 6, 14.06.2016, p. 1093-1112.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
AU - Mitchell, Sarah J.
AU - Madrigal-Matute, Julio
AU - Scheibye-Knudsen, Morten
AU - Fang, Evandro
AU - Aon, Miguel
AU - Gonzalez-Reyes, Jose A.
AU - Cortassa, Sonia
AU - Kaushik, Susmita
AU - Gonzalez-Freire, Marta
AU - Patel, Bindi
AU - Wahl, Devin
AU - Ali, Ahmed
AU - Calvo-Rubio, Miguel
AU - Buron, Maria I.
AU - Guiterrez, Vincent
AU - Ward, Theresa M.
AU - Palacios, Hector H.
AU - Cai, Huan
AU - Frederick, David W.
AU - Hine, Christopher
AU - Broeskamp, Filomena
AU - Habering, Lukas
AU - Dawson, John
AU - Beasley, T. Mark
AU - Wan, Junxiang
AU - Ikeno, Yuji
AU - Hubbard, Gene
AU - Becker, Kevin G.
AU - Zhang, Yongqing
AU - Bohr, Vilhelm A.
AU - Longo, Dan L.
AU - Navas, Placido
AU - Ferrucci, Luigi
AU - Sinclair, David A.
AU - Cohen, Pinchas
AU - Egan, Josephine M.
AU - Mitchell, James R.
AU - Baur, Joseph A.
AU - Allison, David B.
AU - Anson, R. Michael
AU - Villalba, Jose M.
AU - Madeo, Frank
AU - Cuervo, Ana Maria
AU - Pearson, Kevin J.
AU - Ingram, Donald K.
AU - Bernier, Michel
AU - de Cabo, Rafael
PY - 2016/6/14
Y1 - 2016/6/14
N2 - Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle together with fatty acid fueling of mitochondria. CR prevented ageassociated decline in the liver proteostasis network while increasing mitochondrial number, preserving mitochondrial ultrastructure and function with age. Abrogation of mitochondrial function negated life-prolonging effects of CR in yeast and worms. Our data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.
AB - Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However, there are a number of emerging experimental variables that alter CR responses. We investigated the role of sex, strain, and level of CR on health and survival in mice. CR did not always correlate with lifespan extension, although it consistently improved health across strains and sexes. Transcriptional and metabolomics changes driven by CR in liver indicated anaplerotic filling of the Krebs cycle together with fatty acid fueling of mitochondria. CR prevented ageassociated decline in the liver proteostasis network while increasing mitochondrial number, preserving mitochondrial ultrastructure and function with age. Abrogation of mitochondrial function negated life-prolonging effects of CR in yeast and worms. Our data illustrate the complexity of CR in the context of aging, with a clear separation of outcomes related to health and survival, highlighting complexities of translation of CR into human interventions.
U2 - 10.1016/j.cmet.2016.05.027
DO - 10.1016/j.cmet.2016.05.027
M3 - Journal article
C2 - 27304509
VL - 23
SP - 1093
EP - 1112
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 6
ER -
ID: 166500486