Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii). / Wambugu, SN; Towett, PK; Kiama, SG; Abelson, Klas; Kanui, Titus I.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 33, No. 4, 08.2010, p. 347-351.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wambugu, SN, Towett, PK, Kiama, SG, Abelson, K & Kanui, TI 2010, 'Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)', Journal of Veterinary Pharmacology and Therapeutics, vol. 33, no. 4, pp. 347-351. https://doi.org/10.1111/j.1365-2885.2009.01148.x

APA

Wambugu, SN., Towett, PK., Kiama, SG., Abelson, K., & Kanui, T. I. (2010). Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii). Journal of Veterinary Pharmacology and Therapeutics, 33(4), 347-351. https://doi.org/10.1111/j.1365-2885.2009.01148.x

Vancouver

Wambugu SN, Towett PK, Kiama SG, Abelson K, Kanui TI. Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii). Journal of Veterinary Pharmacology and Therapeutics. 2010 Aug;33(4):347-351. https://doi.org/10.1111/j.1365-2885.2009.01148.x

Author

Wambugu, SN ; Towett, PK ; Kiama, SG ; Abelson, Klas ; Kanui, Titus I. / Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii). In: Journal of Veterinary Pharmacology and Therapeutics. 2010 ; Vol. 33, No. 4. pp. 347-351.

Bibtex

@article{902fb30aa9f24017984f6c0a6dcad079,
title = "Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)",
abstract = "Little is known about analgesia in lower vertebrates such as the Speke's hinged tortoise (Kinixy's spekii), yet of late they are increasingly being adopted as pets. The effects of morphine (5, 7.5, 10 and 20 mg/kg), pethidine (10, 20, and 50 mg/kg) and naloxone (5 mg/kg) on nociception induced by the formalin test (12.5%, 100 microL) were studied in the Speke's hinged tortoise. Formalin induced a monophasic limb retraction behavioural response and its duration was recorded. The behaviour lasted for 16.4 +/- 0.8 min. Morphine (7.5, 10 and 20 mg/kg) and pethidine (20 and 50 mg/kg) induced significant decrease in the duration of limb retraction in the formalin test. The anti-nociceptive effects were naloxone (5 mg/kg) reversible. The data suggest that the formalin test is a good test for studying nociception and anti-nociception in tortoises and that the opioidergic system plays a role in the control of nociception in these animals.",
author = "SN Wambugu and PK Towett and SG Kiama and Klas Abelson and Kanui, {Titus I}",
year = "2010",
month = aug,
doi = "10.1111/j.1365-2885.2009.01148.x",
language = "English",
volume = "33",
pages = "347--351",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
issn = "0140-7783",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of opioids in the formalin test in the Speke's hinged tortoise (Kinixy's spekii)

AU - Wambugu, SN

AU - Towett, PK

AU - Kiama, SG

AU - Abelson, Klas

AU - Kanui, Titus I

PY - 2010/8

Y1 - 2010/8

N2 - Little is known about analgesia in lower vertebrates such as the Speke's hinged tortoise (Kinixy's spekii), yet of late they are increasingly being adopted as pets. The effects of morphine (5, 7.5, 10 and 20 mg/kg), pethidine (10, 20, and 50 mg/kg) and naloxone (5 mg/kg) on nociception induced by the formalin test (12.5%, 100 microL) were studied in the Speke's hinged tortoise. Formalin induced a monophasic limb retraction behavioural response and its duration was recorded. The behaviour lasted for 16.4 +/- 0.8 min. Morphine (7.5, 10 and 20 mg/kg) and pethidine (20 and 50 mg/kg) induced significant decrease in the duration of limb retraction in the formalin test. The anti-nociceptive effects were naloxone (5 mg/kg) reversible. The data suggest that the formalin test is a good test for studying nociception and anti-nociception in tortoises and that the opioidergic system plays a role in the control of nociception in these animals.

AB - Little is known about analgesia in lower vertebrates such as the Speke's hinged tortoise (Kinixy's spekii), yet of late they are increasingly being adopted as pets. The effects of morphine (5, 7.5, 10 and 20 mg/kg), pethidine (10, 20, and 50 mg/kg) and naloxone (5 mg/kg) on nociception induced by the formalin test (12.5%, 100 microL) were studied in the Speke's hinged tortoise. Formalin induced a monophasic limb retraction behavioural response and its duration was recorded. The behaviour lasted for 16.4 +/- 0.8 min. Morphine (7.5, 10 and 20 mg/kg) and pethidine (20 and 50 mg/kg) induced significant decrease in the duration of limb retraction in the formalin test. The anti-nociceptive effects were naloxone (5 mg/kg) reversible. The data suggest that the formalin test is a good test for studying nociception and anti-nociception in tortoises and that the opioidergic system plays a role in the control of nociception in these animals.

U2 - 10.1111/j.1365-2885.2009.01148.x

DO - 10.1111/j.1365-2885.2009.01148.x

M3 - Journal article

C2 - 20646195

VL - 33

SP - 347

EP - 351

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 4

ER -

ID: 33810999