Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity
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Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity. / Magkos, Faidon; Fraterrigo, Gemma; Yoshino, Jun; Luecking, Courtney; Kirbach, Kyleigh; Kelly, Shannon C; de Las Fuentes, Lisa; He, Songbing; Okunade, Adewole L; Patterson, Bruce W; Klein, Samuel.
In: Cell Metabolism, Vol. 23, No. 4, 2016, p. 591-601.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity
AU - Magkos, Faidon
AU - Fraterrigo, Gemma
AU - Yoshino, Jun
AU - Luecking, Courtney
AU - Kirbach, Kyleigh
AU - Kelly, Shannon C
AU - de Las Fuentes, Lisa
AU - He, Songbing
AU - Okunade, Adewole L
AU - Patterson, Bruce W
AU - Klein, Samuel
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways.
AB - Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β cell function and insulin sensitivity in muscle and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling, and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways.
KW - Adipose Tissue/metabolism
KW - Adult
KW - Female
KW - Humans
KW - Insulin/metabolism
KW - Insulin Resistance
KW - Insulin-Secreting Cells/metabolism
KW - Liver/metabolism
KW - Male
KW - Middle Aged
KW - Muscles/metabolism
KW - Obesity/metabolism
KW - Weight Loss
U2 - 10.1016/j.cmet.2016.02.005
DO - 10.1016/j.cmet.2016.02.005
M3 - Journal article
C2 - 26916363
VL - 23
SP - 591
EP - 601
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 4
ER -
ID: 289960744