Effects of growth hormone on glucose and fat metabolism in human subjects
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Effects of growth hormone on glucose and fat metabolism in human subjects. / Jørgensen, Jens O L; Møller, Louise; Krag, Morten Brøgger; Billestrup, Nils; Christiansen, Jens Kristian S.
In: Endocrinology & Metabolism Clinics of North America, Vol. 36, No. 1, 01.03.2007, p. 75-87.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of growth hormone on glucose and fat metabolism in human subjects
AU - Jørgensen, Jens O L
AU - Møller, Louise
AU - Krag, Morten Brøgger
AU - Billestrup, Nils
AU - Christiansen, Jens Kristian S.
PY - 2007/3/1
Y1 - 2007/3/1
N2 - This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.
AB - This article focuses on in vivo data from tests performed in normal subjects and in patients who had abnormal growth hormone (GH) status. Experimental data in human subjects demonstrate that GH acutely inhibits glucose disposal in skeletal muscle. At the same time GH stimulates the turnover and oxidation of free fatty acid (FFA), and experimental evidence suggests a causal link between elevated FFA levels and insulin resistance in skeletal muscle. Observational data in GH-deficient adults do not indicate that GH replacement is associated with significant impairment of glucose tolerance, but it is recommended that overdosing be avoided and glycemic control be monitored.
KW - Fasting
KW - Glucose
KW - Growth Hormone
KW - Humans
KW - Insulin Resistance
KW - Lipid Metabolism
KW - Models, Biological
KW - Research Subjects
U2 - 10.1016/j.ecl.2006.11.005
DO - 10.1016/j.ecl.2006.11.005
M3 - Journal article
C2 - 17336735
VL - 36
SP - 75
EP - 87
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
SN - 0889-8529
IS - 1
ER -
ID: 33903242