Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial
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Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial. / Bjørnshave, Ann; Lykkeboe, Simon; Hartmann, Bolette; Holst, Jens J.; Hermansen, Kjeld; Starup-Linde, Jakob.
In: Diabetic Medicine, Vol. 38, No. 6, e14471, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of a whey protein pre-meal on bone turnover in participants with and without type 2 diabetes - A post hoc analysis of a randomised, controlled, crossover trial
AU - Bjørnshave, Ann
AU - Lykkeboe, Simon
AU - Hartmann, Bolette
AU - Holst, Jens J.
AU - Hermansen, Kjeld
AU - Starup-Linde, Jakob
PY - 2021
Y1 - 2021
N2 - Aims Whey protein may improve bone turnover and have anti-osteoporotic effects. The aim of the present randomised, controlled, crossover trial was to evaluate the effects of a whey protein pre-meal on bone turnover in people with type 2 diabetes and controls.Methods Two groups, matched on sex, age and body mass index, comprising 12 participants with and 12 participants without type 2 diabetes were randomly given a pre-meal of whey protein (20 g) or water, which was consumed 15 min before a fat-rich meal or a fat-rich meal supplemented with 20 g whey protein. During a 360-min period, postprandial responses in bone turnover were examined.Results Osteocalcin, P-procollagen type 1 amino terminal propeptide (P1NP), C-terminal cross-linked telopeptide of type-I collagen (CTX) and parathyroid hormone (PTH) were lower at baseline and PTH, osteocalcin and P1NP were lower during the entire postprandial phase in participants with type 2 diabetes than in participants without type 2 diabetes. We observed similar postprandial responses in bone turnover markers between persons with and without type 2 diabetes. We observed no effect of the whey protein or the water pre-meal on bone turnover markers. The changes were unrelated to secretion of hormones of the gut-bone axis.Conclusion Osteocalcin, P1NP, CTX and PTH all decreased following meal ingestion. We observed no convincing effect of a whey protein pre-meal on bone turnover. However, these results confirm that people with type 2 diabetes have low bone turnover and that the decreased bone formation markers are also extend into the postprandial responses.
AB - Aims Whey protein may improve bone turnover and have anti-osteoporotic effects. The aim of the present randomised, controlled, crossover trial was to evaluate the effects of a whey protein pre-meal on bone turnover in people with type 2 diabetes and controls.Methods Two groups, matched on sex, age and body mass index, comprising 12 participants with and 12 participants without type 2 diabetes were randomly given a pre-meal of whey protein (20 g) or water, which was consumed 15 min before a fat-rich meal or a fat-rich meal supplemented with 20 g whey protein. During a 360-min period, postprandial responses in bone turnover were examined.Results Osteocalcin, P-procollagen type 1 amino terminal propeptide (P1NP), C-terminal cross-linked telopeptide of type-I collagen (CTX) and parathyroid hormone (PTH) were lower at baseline and PTH, osteocalcin and P1NP were lower during the entire postprandial phase in participants with type 2 diabetes than in participants without type 2 diabetes. We observed similar postprandial responses in bone turnover markers between persons with and without type 2 diabetes. We observed no effect of the whey protein or the water pre-meal on bone turnover markers. The changes were unrelated to secretion of hormones of the gut-bone axis.Conclusion Osteocalcin, P1NP, CTX and PTH all decreased following meal ingestion. We observed no convincing effect of a whey protein pre-meal on bone turnover. However, these results confirm that people with type 2 diabetes have low bone turnover and that the decreased bone formation markers are also extend into the postprandial responses.
KW - bone turnover
KW - type 2 diabetes
KW - meal
KW - gastrointestinal hormones
KW - PARATHYROID-HORMONE
KW - GLUCOSE
KW - SUPPLEMENTATION
KW - RESORPTION
KW - MELLITUS
KW - MARKERS
KW - MECHANISMS
KW - FRACTURES
KW - DENSITY
KW - RISK
U2 - 10.1111/dme.14471
DO - 10.1111/dme.14471
M3 - Journal article
C2 - 33259643
VL - 38
JO - Diabetic Medicine Online
JF - Diabetic Medicine Online
SN - 1464-5491
IS - 6
M1 - e14471
ER -
ID: 253649060