Effectiveness of low-level laser therapy associated with strength training in knee osteoarthritis: Protocol for a randomized placebo-controlled trial
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Effectiveness of low-level laser therapy associated with strength training in knee osteoarthritis : Protocol for a randomized placebo-controlled trial. / Stausholm, Martin Bjørn; Naterstad, Ingvill Fjell; Couppé, Christian; Fersum, Kjartan Vibe; Leal-Junior, Ernesto Cesar Pinto; Lopes-Martins, Rodrigo Álvaro Brandão; Bjordal, Jan Magnus; Joensen, Jon.
In: Methods and Protocols, Vol. 4, No. 1, 19, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effectiveness of low-level laser therapy associated with strength training in knee osteoarthritis
T2 - Protocol for a randomized placebo-controlled trial
AU - Stausholm, Martin Bjørn
AU - Naterstad, Ingvill Fjell
AU - Couppé, Christian
AU - Fersum, Kjartan Vibe
AU - Leal-Junior, Ernesto Cesar Pinto
AU - Lopes-Martins, Rodrigo Álvaro Brandão
AU - Bjordal, Jan Magnus
AU - Joensen, Jon
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Physical activity and low-level laser therapy (LLLT) can reduce knee osteoarthritis (KOA) inflammation. We are conducting a randomized placebo-controlled trial to investigate the long-term effectiveness of LLLT combined with strength training (ST) in persons with KOA, since it, to our knowledge, has not been investigated before. Fifty participants were enrolled. LLLT and ST was performed 3 times per week over 3 and 8 weeks, respectively. In the LLLT group, 3 Joules of 904 nm wavelength laser was applied to 15 spots per knee (45 Joules/knee/session). The primary outcomes are pain during movement, at night and at rest (Visual Analogue Scale) and global pain (Knee injury and Osteoarthritis Outcome Score, KOOS) pain subscale. The secondary outcomes are KOOS disability and quality-of-life, analgesic usage, global health change, knee active range of motion, 30 s chair stand, maximum painless isometric knee extension strength, knee pain pressure threshold and real-time ultrasonography-assessed suprapatellar effusion, meniscal neovascularization and femur cartilage thickness. All the outcomes are assessed 0, 3, 8, 26 and 52 weeks post-randomization, except for global health change, which is only evaluated at completed ST. This study features the blinding of participants, assessors and therapists, and will improve our understanding of what occurs with the local pathophysiology, tissue morphology and clinical status of persons with KOA up to a year after the initiation of ST and a higher 904 nm LLLT dose than in any published trial on this topic.
AB - Physical activity and low-level laser therapy (LLLT) can reduce knee osteoarthritis (KOA) inflammation. We are conducting a randomized placebo-controlled trial to investigate the long-term effectiveness of LLLT combined with strength training (ST) in persons with KOA, since it, to our knowledge, has not been investigated before. Fifty participants were enrolled. LLLT and ST was performed 3 times per week over 3 and 8 weeks, respectively. In the LLLT group, 3 Joules of 904 nm wavelength laser was applied to 15 spots per knee (45 Joules/knee/session). The primary outcomes are pain during movement, at night and at rest (Visual Analogue Scale) and global pain (Knee injury and Osteoarthritis Outcome Score, KOOS) pain subscale. The secondary outcomes are KOOS disability and quality-of-life, analgesic usage, global health change, knee active range of motion, 30 s chair stand, maximum painless isometric knee extension strength, knee pain pressure threshold and real-time ultrasonography-assessed suprapatellar effusion, meniscal neovascularization and femur cartilage thickness. All the outcomes are assessed 0, 3, 8, 26 and 52 weeks post-randomization, except for global health change, which is only evaluated at completed ST. This study features the blinding of participants, assessors and therapists, and will improve our understanding of what occurs with the local pathophysiology, tissue morphology and clinical status of persons with KOA up to a year after the initiation of ST and a higher 904 nm LLLT dose than in any published trial on this topic.
KW - Inflammation, knee osteoarthritis
KW - LLLT
KW - Low-level laser therapy
KW - Strength training
U2 - 10.3390/MPS4010019
DO - 10.3390/MPS4010019
M3 - Journal article
AN - SCOPUS:85102945905
VL - 4
JO - Methods and Protocols
JF - Methods and Protocols
SN - 2409-9279
IS - 1
M1 - 19
ER -
ID: 303766809