Effect of new manganese contrast agent on tissue intensities in human volunteers: Comparison of 0.23, 0.6 and 1.5T MRI, a part of a phase I trail
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Effect of new manganese contrast agent on tissue intensities in human volunteers : Comparison of 0.23, 0.6 and 1.5T MRI, a part of a phase I trail. / Chabanova, E.; Thomsen, H. S.; Løgager, V.; Moller, J. M.; Brage, K.; Fogh, K.; Bovin, J.; Elmig, J.
In: Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 17, No. 1, 01.01.2004, p. 28-35.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of new manganese contrast agent on tissue intensities in human volunteers
T2 - Comparison of 0.23, 0.6 and 1.5T MRI, a part of a phase I trail
AU - Chabanova, E.
AU - Thomsen, H. S.
AU - Løgager, V.
AU - Moller, J. M.
AU - Brage, K.
AU - Fogh, K.
AU - Bovin, J.
AU - Elmig, J.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - To evaluate the effect of a new oral manganese contrast agent (CMC-001) on magnetic resonance imaging (MRI) intensities at different magnetic field strengths. Twelve healthy volunteers underwent abdominal MRI 1 week before and within 2.5-4.5 h after CMC-001 (MnCl2 and absorption promoters dissolved in water) intake at three different MR scanners of 0.23, 0.6 and 1.5 T. Image contrast and intensity enhancement of liver and pancreas were analysed relatively to muscle and fat intensities. Manganese blood levels were allowed for 24 h. Whole-blood Manganese concentration levels stayed within the normal range. The liver intensities on T2w images decreased about 10% for the 1/2 contrast dose and about 20% for the full contrast dose independent of the field strength. The liver intensities on T1w images increased more than 30% for 1/2 contrast dose and over 40% for full contrast dose. The maximum T1 enhancement was achieved at the highest field. Pancreas intensities were not affected. Contrast between liver, muscle and fat intensities increased with magnetic field, as well as standard errors of the volunteer-averaged intensities. Oral intake of CMC-001 influences liver intensities and does not affect pancreas intensities at different magnetic field strengths.
AB - To evaluate the effect of a new oral manganese contrast agent (CMC-001) on magnetic resonance imaging (MRI) intensities at different magnetic field strengths. Twelve healthy volunteers underwent abdominal MRI 1 week before and within 2.5-4.5 h after CMC-001 (MnCl2 and absorption promoters dissolved in water) intake at three different MR scanners of 0.23, 0.6 and 1.5 T. Image contrast and intensity enhancement of liver and pancreas were analysed relatively to muscle and fat intensities. Manganese blood levels were allowed for 24 h. Whole-blood Manganese concentration levels stayed within the normal range. The liver intensities on T2w images decreased about 10% for the 1/2 contrast dose and about 20% for the full contrast dose independent of the field strength. The liver intensities on T1w images increased more than 30% for 1/2 contrast dose and over 40% for full contrast dose. The maximum T1 enhancement was achieved at the highest field. Pancreas intensities were not affected. Contrast between liver, muscle and fat intensities increased with magnetic field, as well as standard errors of the volunteer-averaged intensities. Oral intake of CMC-001 influences liver intensities and does not affect pancreas intensities at different magnetic field strengths.
KW - Contrast agent
KW - Liver
KW - Manganese
KW - MRI
KW - Oral intake
UR - http://www.scopus.com/inward/record.url?scp=6344291761&partnerID=8YFLogxK
U2 - 10.1007/s10334-004-0042-z
DO - 10.1007/s10334-004-0042-z
M3 - Journal article
C2 - 15258827
AN - SCOPUS:6344291761
VL - 17
SP - 28
EP - 35
JO - Magnetic Resonance Materials in Physics, Biology, and Medicine
JF - Magnetic Resonance Materials in Physics, Biology, and Medicine
SN - 0968-5243
IS - 1
ER -
ID: 222709153