Effect of gastrin on liver regeneration after partial hepatectomy in rats
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Effect of gastrin on liver regeneration after partial hepatectomy in rats. / Poulsen, Steen Seier; Olsen, P S.
In: Gut, Vol. 31, No. 1, 01.1990, p. 92-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of gastrin on liver regeneration after partial hepatectomy in rats
AU - Poulsen, Steen Seier
AU - Olsen, P S
PY - 1990/1
Y1 - 1990/1
N2 - Gastrin has been shown to be an important trophic hormone for the mucosa of the stomach and the proximal intestine. In the present study the effect of gastrin on liver regeneration after partial hepatectomy in rats was investigated. After partial hepatectomy a significant rise in the concentration of gastrin in portal venous blood was found six, 12, and 18 hours after 70% hepatectomy. The effect of changes in the endogenous gastrin concentration on the liver regeneration was investigated in rats subjected to antrectomy or to fundectomy. Partial hepatectomy was done three weeks after the primary surgery. We found antrectomy to decrease liver regeneration, whereas fundectomy had no effect. Administration of pentagastrin 300 micrograms/kg sc three times daily for two and four days after partial hepatectomy significantly increased the rate of liver regeneration compared with controls. This study suggests that gastrin has a hepatotrophic effect. Whether this effect is caused by a direct action of gastrin on the hepatocytes or it is an indirect effect mediated by for instance insulin, glucagon or epidermal growth factor has to be further investigated.
AB - Gastrin has been shown to be an important trophic hormone for the mucosa of the stomach and the proximal intestine. In the present study the effect of gastrin on liver regeneration after partial hepatectomy in rats was investigated. After partial hepatectomy a significant rise in the concentration of gastrin in portal venous blood was found six, 12, and 18 hours after 70% hepatectomy. The effect of changes in the endogenous gastrin concentration on the liver regeneration was investigated in rats subjected to antrectomy or to fundectomy. Partial hepatectomy was done three weeks after the primary surgery. We found antrectomy to decrease liver regeneration, whereas fundectomy had no effect. Administration of pentagastrin 300 micrograms/kg sc three times daily for two and four days after partial hepatectomy significantly increased the rate of liver regeneration compared with controls. This study suggests that gastrin has a hepatotrophic effect. Whether this effect is caused by a direct action of gastrin on the hepatocytes or it is an indirect effect mediated by for instance insulin, glucagon or epidermal growth factor has to be further investigated.
KW - Animals
KW - DNA
KW - Gastrins
KW - Hepatectomy
KW - Liver
KW - Liver Regeneration
KW - Male
KW - Organ Size
KW - Pentagastrin
KW - Pyloric Antrum
KW - Rats
KW - Rats, Inbred Strains
KW - Time Factors
M3 - Journal article
C2 - 2318436
VL - 31
SP - 92
EP - 95
JO - Gut
JF - Gut
SN - 0017-5749
IS - 1
ER -
ID: 47488178